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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
2004-10-7
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pubmed:abstractText |
The widespread use of prostate-specific antigen (PSA) testing to screen for prostate carcinoma has led to significant overdiagnosis, due to the frequent detection of indolent malignancies on PSA screening. The detection of abnormal PSA levels typically is followed by ultrasound-guided needle biopsy. Therefore, in an effort to identify genetic markers that augment the information provided by standard histopathologic classification, the authors tested the feasibility of using these minute biopsy samples for genomic profiling via chromosome banding analysis and comparative genomic hybridization (CGH).
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0008-543X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
101
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1786-93
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:15386312-Aged,
pubmed-meshheading:15386312-Biopsy,
pubmed-meshheading:15386312-Cell Differentiation,
pubmed-meshheading:15386312-Chromosome Aberrations,
pubmed-meshheading:15386312-Chromosome Banding,
pubmed-meshheading:15386312-Chromosomes, Human, Pair 16,
pubmed-meshheading:15386312-DNA, Neoplasm,
pubmed-meshheading:15386312-Decision Making,
pubmed-meshheading:15386312-Feasibility Studies,
pubmed-meshheading:15386312-Humans,
pubmed-meshheading:15386312-Karyotyping,
pubmed-meshheading:15386312-Male,
pubmed-meshheading:15386312-Middle Aged,
pubmed-meshheading:15386312-Nucleic Acid Hybridization,
pubmed-meshheading:15386312-Preoperative Care,
pubmed-meshheading:15386312-Prognosis,
pubmed-meshheading:15386312-Prostate-Specific Antigen,
pubmed-meshheading:15386312-Prostatic Intraepithelial Neoplasia,
pubmed-meshheading:15386312-Prostatic Neoplasms
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pubmed:year |
2004
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pubmed:articleTitle |
Genomic analysis of prostate carcinoma specimens obtained via ultrasound-guided needle biopsy may be of use in preoperative decision-making.
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pubmed:affiliation |
Department of Genetics, Portuguese Oncology Institute, Porto, Portugal. mteixeir@ipoporto.min-saude.pt
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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