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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
2004-9-22
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pubmed:abstractText |
It was recently demonstrated that there are CD4(+) macrophages, which exhibit strong phagocytic activity, in the thymus. They are suggested to play an important role for the elimination of apoptotic thymocytes. However, the origin and nature of CD4(+) macrophages in the thymus remain unexplored. In this study, we describe that the most immature intrathymic progenitors (CD25(-)/CD44(+)/FcR(+)) give rise to CD4(+) macrophages by oncostatin M-responsive thymic epithelial cells (ORTEC) in an IL-7-dependent manner. Neither conditioned medium of ORTEC nor a mixture of cytokines induced CD4(+) macrophages, and oncostatin M receptor was not expressed in thymocytes, suggesting that the development of CD4(+) macrophages from the immature thymocytes requires a direct interaction with ORTEC. These results collectively suggest that the development of CD4(+) macrophages from the intrathymic T cell progenitors is induced by thymic epithelial cells.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0022-1767
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
173
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4360-7
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:15383565-Animals,
pubmed-meshheading:15383565-Antigens, CD11b,
pubmed-meshheading:15383565-Antigens, CD4,
pubmed-meshheading:15383565-Cell Communication,
pubmed-meshheading:15383565-Cell Differentiation,
pubmed-meshheading:15383565-Cell Line,
pubmed-meshheading:15383565-Cells, Cultured,
pubmed-meshheading:15383565-Cytokines,
pubmed-meshheading:15383565-Epithelial Cells,
pubmed-meshheading:15383565-Fetus,
pubmed-meshheading:15383565-Interleukin-7,
pubmed-meshheading:15383565-Lymphocyte Subsets,
pubmed-meshheading:15383565-Macrophages,
pubmed-meshheading:15383565-Mice,
pubmed-meshheading:15383565-Mice, Inbred C57BL,
pubmed-meshheading:15383565-Oncostatin M,
pubmed-meshheading:15383565-Peptides,
pubmed-meshheading:15383565-Stem Cells,
pubmed-meshheading:15383565-Thymus Gland
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pubmed:year |
2004
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pubmed:articleTitle |
Development of CD4+ macrophages from intrathymic T cell progenitors is induced by thymic epithelial cells.
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pubmed:affiliation |
Institute of Molecular and Cellular Biosciences, University of Tokyo, Tokyo, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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