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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2004-9-16
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pubmed:abstractText |
Collagen plays a major role in arterial wall remodeling, aneurysm formation, and atherosclerotic cap stability. Smokers often have weakened arterial walls associating with aneurysm and thinned atherosclerotic plaque caps leading to rupture and acute coronary syndromes. We hypothesize that these detrimental effects on arterial wall by tobacco are partially mediated by disturbed collagen metabolism.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0006-291X
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 2004 Elsevier Inc.
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
323
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
592-8
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:15369792-Acrolein,
pubmed-meshheading:15369792-Aorta, Abdominal,
pubmed-meshheading:15369792-Benzo(a)pyrene,
pubmed-meshheading:15369792-Cells, Cultured,
pubmed-meshheading:15369792-Collagen,
pubmed-meshheading:15369792-Coronary Artery Disease,
pubmed-meshheading:15369792-Down-Regulation,
pubmed-meshheading:15369792-Endothelial Cells,
pubmed-meshheading:15369792-Gene Expression Regulation, Enzymologic,
pubmed-meshheading:15369792-Humans,
pubmed-meshheading:15369792-Muscle, Smooth, Vascular,
pubmed-meshheading:15369792-Nicotine,
pubmed-meshheading:15369792-Plant Extracts,
pubmed-meshheading:15369792-Procollagen-Proline Dioxygenase,
pubmed-meshheading:15369792-RNA, Messenger,
pubmed-meshheading:15369792-Smoke,
pubmed-meshheading:15369792-Smoking,
pubmed-meshheading:15369792-Tobacco
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pubmed:year |
2004
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pubmed:articleTitle |
Cigarette suppresses the expression of P4Halpha and vascular collagen production.
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pubmed:affiliation |
Division of Cardiothoracic Surgery, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX, USA.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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