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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
19
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pubmed:dateCreated |
2004-9-15
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pubmed:abstractText |
The regulation of TT virus (TTV) gene expression was characterized. Transient-transfection assays using reporter constructs revealed that a 113-nucleotide (nt) sequence within the untranslated region, proximal to the transcription initiation site and containing a TATA box motif, has a basal promoter activity. This sequence is well conserved among different TTV genotypes. Upstream stimulating factor bound to a consensus binding motif within this region and positively regulates TTV transcription. Furthermore, a 488-nt region upstream of the basal promoter exhibited enhancer activity, presumably in a cell type-specific manner. This study illustrates some of the mechanisms involved in the transcriptional regulation of TTV.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/15367649-10077657,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15367649-10196248,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15367649-10405352,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15367649-10423144,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15367649-10516475,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15367649-10523835,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15367649-10971131,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15367649-11024126,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15367649-11118348,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15367649-11915042,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15367649-11987140,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15367649-14517056,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15367649-2249772,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15367649-7523363,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15367649-9144210,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15367649-9242925,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15367649-9597751,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15367649-9770428
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0022-538X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
78
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
10820-4
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:15367649-Artificial Gene Fusion,
pubmed-meshheading:15367649-Base Sequence,
pubmed-meshheading:15367649-Consensus Sequence,
pubmed-meshheading:15367649-DNA-Binding Proteins,
pubmed-meshheading:15367649-Enhancer Elements, Genetic,
pubmed-meshheading:15367649-Gene Expression Regulation, Viral,
pubmed-meshheading:15367649-Genes, Reporter,
pubmed-meshheading:15367649-Luciferases,
pubmed-meshheading:15367649-Molecular Sequence Data,
pubmed-meshheading:15367649-Promoter Regions, Genetic,
pubmed-meshheading:15367649-Protein Binding,
pubmed-meshheading:15367649-TATA Box,
pubmed-meshheading:15367649-Torque teno virus,
pubmed-meshheading:15367649-Transcription, Genetic,
pubmed-meshheading:15367649-Transcription Factors,
pubmed-meshheading:15367649-Untranslated Regions,
pubmed-meshheading:15367649-Upstream Stimulatory Factors
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pubmed:year |
2004
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pubmed:articleTitle |
Identification of basal promoter and enhancer elements in an untranslated region of the TT virus genome.
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pubmed:affiliation |
Department of Virology II, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku-ku, Tokyo 162-8640, Japan. tesuzuki@nih.go.jp
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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