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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2004-9-14
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pubmed:abstractText |
Retinal bipolar cells are essential to the transmission of light information. Although bipolar cell dysfunction can result in blindness, little is known about the factors required for bipolar cell development and functional maturation. The basic helix-loop-helix (bHLH) transcription factor Bhlhb4 was found to be expressed in rod bipolar cells (RB). Electroretinograms (ERGs) in the adult Bhlhb4 knockout (Bhlhb4(-/-)) showed that the loss of Bhlhb4 resulted in disrupted rod signaling and profound retinal dysfunction resembling human congenital stationary night blindness (CSNB), characterized by the loss of the scotopic ERG b-wave. A depletion of inner nuclear layer (INL) cells in the adult Bhlhb4 knockout has been ascribed to the abolishment of the RB cell population during postnatal development. Other retinal cell populations including photoreceptors were unaltered. The timing of RB cell depletion in the Bhlhb4(-/-) mouse suggests that Bhlhb4 is essential for RB cell maturation.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Basic Helix-Loop-Helix...,
http://linkedlifedata.com/resource/pubmed/chemical/Bhlhb4 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/CASP3 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Ca2 -binding protein-1,
http://linkedlifedata.com/resource/pubmed/chemical/Calcium-Binding Protein, Vitamin...,
http://linkedlifedata.com/resource/pubmed/chemical/Calcium-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Casp3 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Casp3 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Caspase 3,
http://linkedlifedata.com/resource/pubmed/chemical/Caspases,
http://linkedlifedata.com/resource/pubmed/chemical/Eye Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/GTP-Binding Protein alpha...,
http://linkedlifedata.com/resource/pubmed/chemical/Homeodomain Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Indenes,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Transport Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Nerve Tissue Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/PAX6 protein,
http://linkedlifedata.com/resource/pubmed/chemical/Paired Box Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Prkca protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Kinase C,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Kinase C-alpha,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Repressor Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/S100 Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/SV2C protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Sv2a protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Sv2a protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Sv2c protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Vesicular Glutamate Transport...,
http://linkedlifedata.com/resource/pubmed/chemical/Vesicular Transport Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/beta-Galactosidase,
http://linkedlifedata.com/resource/pubmed/chemical/calbindin,
http://linkedlifedata.com/resource/pubmed/chemical/calretinin
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0896-6273
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
16
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pubmed:volume |
43
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
779-93
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:15363390-Age Factors,
pubmed-meshheading:15363390-Animals,
pubmed-meshheading:15363390-Mice,
pubmed-meshheading:15363390-Retina,
pubmed-meshheading:15363390-Microscopy, Electron,
pubmed-meshheading:15363390-Neurons,
pubmed-meshheading:15363390-Embryo, Mammalian,
pubmed-meshheading:15363390-Indenes,
pubmed-meshheading:15363390-Electroretinography,
pubmed-meshheading:15363390-Synapses,
pubmed-meshheading:15363390-Cells, Cultured,
pubmed-meshheading:15363390-Eye Proteins,
pubmed-meshheading:15363390-Animals, Newborn,
pubmed-meshheading:15363390-RNA, Messenger,
pubmed-meshheading:15363390-Nerve Tissue Proteins,
pubmed-meshheading:15363390-Fluorescent Antibody Technique,
pubmed-meshheading:15363390-Photic Stimulation,
pubmed-meshheading:15363390-Evoked Potentials,
pubmed-meshheading:15363390-Membrane Transport Proteins,
pubmed-meshheading:15363390-beta-Galactosidase,
pubmed-meshheading:15363390-Cell Count,
pubmed-meshheading:15363390-Cell Aging,
pubmed-meshheading:15363390-Gene Expression Regulation, Developmental,
pubmed-meshheading:15363390-Repressor Proteins,
pubmed-meshheading:15363390-Retinal Rod Photoreceptor Cells,
pubmed-meshheading:15363390-S100 Proteins,
pubmed-meshheading:15363390-Stem Cells,
pubmed-meshheading:15363390-In Situ Hybridization,
pubmed-meshheading:15363390-Transcription Factors,
pubmed-meshheading:15363390-Membrane Glycoproteins,
pubmed-meshheading:15363390-Calcium-Binding Protein, Vitamin D-Dependent,
pubmed-meshheading:15363390-Calcium-Binding Proteins,
pubmed-meshheading:15363390-Gene Expression
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