Source:http://linkedlifedata.com/resource/pubmed/id/15361876
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
10
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| pubmed:dateCreated |
2004-9-28
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| pubmed:abstractText |
The synapse is a highly organized cellular specialization whose structure and composition are reorganized, both positively and negatively, depending on the strength of input signals. The mechanisms orchestrating these changes are not well understood. A plausible locus for the reorganization of synapse components and structure is actin, because it serves as both cytoskeleton and scaffold for synapses and exists in a dynamic equilibrium between F-actin and G-actin that is modulated bidirectionally by cellular signaling. Using a new FRET-based imaging technique to monitor F-actin/G-actin equilibrium, we show here that tetanic stimulation causes a rapid, persistent shift of actin equilibrium toward F-actin in the dendritic spines of rat hippocampal neurons. This enlarges the spines and increases postsynaptic binding capacity. In contrast, prolonged low-frequency stimulation shifts the equilibrium toward G-actin, resulting in a loss of postsynaptic actin and of structure. This bidirectional regulation of actin is actively involved in protein assembly and disassembly and provides a substrate for bidirectional synaptic plasticity.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Oct
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| pubmed:issn |
1097-6256
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
7
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
1104-12
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| pubmed:dateRevised |
2011-11-17
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| pubmed:meshHeading |
pubmed-meshheading:15361876-Actin Cytoskeleton,
pubmed-meshheading:15361876-Actins,
pubmed-meshheading:15361876-Animals,
pubmed-meshheading:15361876-Brain,
pubmed-meshheading:15361876-Calcium-Calmodulin-Dependent Protein Kinase Type 2,
pubmed-meshheading:15361876-Calcium-Calmodulin-Dependent Protein Kinases,
pubmed-meshheading:15361876-Dendritic Spines,
pubmed-meshheading:15361876-Electric Stimulation,
pubmed-meshheading:15361876-Fluorescence Resonance Energy Transfer,
pubmed-meshheading:15361876-Hippocampus,
pubmed-meshheading:15361876-Image Cytometry,
pubmed-meshheading:15361876-Mice,
pubmed-meshheading:15361876-NIH 3T3 Cells,
pubmed-meshheading:15361876-Neuronal Plasticity,
pubmed-meshheading:15361876-Nonlinear Dynamics,
pubmed-meshheading:15361876-Organ Culture Techniques,
pubmed-meshheading:15361876-Protein Binding,
pubmed-meshheading:15361876-Rats,
pubmed-meshheading:15361876-Synaptic Membranes,
pubmed-meshheading:15361876-Synaptic Transmission,
pubmed-meshheading:15361876-Time Factors,
pubmed-meshheading:15361876-Up-Regulation
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| pubmed:year |
2004
|
| pubmed:articleTitle |
Rapid and persistent modulation of actin dynamics regulates postsynaptic reorganization underlying bidirectional plasticity.
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| pubmed:affiliation |
RIKEN-MIT Neuroscience Research Center, The Picower Center for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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