Linked Life Data

15358592

Source:http://linkedlifedata.com/resource/pubmed/id/15358592

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2004-9-10
pubmed:abstractText
Tachykinins represent a family of peptides which have significant effects on such diverse physiological responses as gut peristalsis, vascular permeability, and the transmission of pain. Traditionally, neurons have been identified as the major source of tachykinin peptides in peripheral tissues and in the central nervous system, resulting in their classification as neuropeptides or, more specifically, as neurokinins. The fact that a variety of cell types can express one or more members of the family of neurokinin receptors accounts for the remarkable ability of these tachykinin peptides to affect multiple organ systems and numerous biological responses. Perhaps one of the most surprising findings during the last 15 years has been the understanding that expression of neurokinin receptors on leukocyte populations can be constitutive or inducible. This fact establishes a receptor-mediated mechanism by which tachykinin peptides can affect both innate and specific immune responses. Due to the numerous cytokines, chemokines, and other soluble mediators that can modulate leukocyte responses, the importance of tachykinin-mediated modulation of the immune response has met with some skepticism. The following reviews make a strong case for neurokinin receptor expression by leukocytes as a significant participant in host response. From hematopoiesis to antigen-specific T lymphocyte responses, tachykinins are present and can dramatically modulate maturation and responsiveness of these immune cells. Studies which document this surprising role for neurokinin receptor expression by leukocytes are detailed in the following reviews.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
1093-4715
pubmed:author
pubmed:issnType
Electronic
pubmed:day
1
pubmed:volume
9
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
3331-2
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
2004
pubmed:articleTitle
Tachykinin-mediated modulation of the immune response.
pubmed:affiliation
Department of Biology, University of North Carolina at Charlotte, Charlotte, NC 28223, USA. kbost@email.uncc.edu
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Review, Research Support, N.I.H., Extramural