| pubmed-article:15358124 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15358124 | lifeskim:mentions | umls-concept:C0025255 | lld:lifeskim |
| pubmed-article:15358124 | lifeskim:mentions | umls-concept:C0023779 | lld:lifeskim |
| pubmed-article:15358124 | lifeskim:mentions | umls-concept:C1171362 | lld:lifeskim |
| pubmed-article:15358124 | lifeskim:mentions | umls-concept:C0206518 | lld:lifeskim |
| pubmed-article:15358124 | lifeskim:mentions | umls-concept:C0205409 | lld:lifeskim |
| pubmed-article:15358124 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:15358124 | lifeskim:mentions | umls-concept:C1515670 | lld:lifeskim |
| pubmed-article:15358124 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:15358124 | pubmed:dateCreated | 2004-9-10 | lld:pubmed |
| pubmed-article:15358124 | pubmed:abstractText | Lipid raft domains have attracted much recent attention as platforms for plasma membrane signalling complexes. In particular, evidence is emerging that shows them to be key regulators of G protein coupled receptor function. The G protein coupled gamma-aminobutyric acid receptor B (GABA(B) receptor) co-isolates with lipid raft domains from rat brain cerebellum. In the present study, we show that the GABA(B1a,2) receptor was also present in lipid raft domains when expressed ectopically in a Chinese hamster ovary cell line. Lipid raft-associated receptor was functionally active, displaying a concentration-dependent increase in GTPgammaS binding in response to the receptor agonist GABA. Compared with whole cell membranes, lipid raft-associated receptor displayed an increased EC(50) and a reduced magnitude of response to GABA. We conclude that lipid raft association is an intrinsic property of the GABA(B1a,2) receptor and is not cell-type specific. In addition, localisation to lipid raft domains may provide a mechanism to inhibit receptor function. | lld:pubmed |
| pubmed-article:15358124 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15358124 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15358124 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15358124 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15358124 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15358124 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15358124 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15358124 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15358124 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:15358124 | pubmed:issn | 0006-291X | lld:pubmed |
| pubmed-article:15358124 | pubmed:author | pubmed-author:WiseAlanA | lld:pubmed |
| pubmed-article:15358124 | pubmed:author | pubmed-author:GreenAndrewA | lld:pubmed |
| pubmed-article:15358124 | pubmed:author | pubmed-author:McIlhinneyR... | lld:pubmed |
| pubmed-article:15358124 | pubmed:author | pubmed-author:WhiteJulia... | lld:pubmed |
| pubmed-article:15358124 | pubmed:author | pubmed-author:IgeAntoinette... | lld:pubmed |
| pubmed-article:15358124 | pubmed:author | pubmed-author:BecherAnjaA | lld:pubmed |
| pubmed-article:15358124 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15358124 | pubmed:day | 3 | lld:pubmed |
| pubmed-article:15358124 | pubmed:volume | 321 | lld:pubmed |
| pubmed-article:15358124 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15358124 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15358124 | pubmed:pagination | 981-7 | lld:pubmed |
| pubmed-article:15358124 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
| pubmed-article:15358124 | pubmed:meshHeading | pubmed-meshheading:15358124... | lld:pubmed |
| pubmed-article:15358124 | pubmed:meshHeading | pubmed-meshheading:15358124... | lld:pubmed |
| pubmed-article:15358124 | pubmed:meshHeading | pubmed-meshheading:15358124... | lld:pubmed |
| pubmed-article:15358124 | pubmed:meshHeading | pubmed-meshheading:15358124... | lld:pubmed |
| pubmed-article:15358124 | pubmed:meshHeading | pubmed-meshheading:15358124... | lld:pubmed |
| pubmed-article:15358124 | pubmed:meshHeading | pubmed-meshheading:15358124... | lld:pubmed |
| pubmed-article:15358124 | pubmed:meshHeading | pubmed-meshheading:15358124... | lld:pubmed |
| pubmed-article:15358124 | pubmed:meshHeading | pubmed-meshheading:15358124... | lld:pubmed |
| pubmed-article:15358124 | pubmed:meshHeading | pubmed-meshheading:15358124... | lld:pubmed |
| pubmed-article:15358124 | pubmed:meshHeading | pubmed-meshheading:15358124... | lld:pubmed |
| pubmed-article:15358124 | pubmed:meshHeading | pubmed-meshheading:15358124... | lld:pubmed |
| pubmed-article:15358124 | pubmed:meshHeading | pubmed-meshheading:15358124... | lld:pubmed |
| pubmed-article:15358124 | pubmed:meshHeading | pubmed-meshheading:15358124... | lld:pubmed |
| pubmed-article:15358124 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:15358124 | pubmed:articleTitle | Ectopically expressed gamma-aminobutyric acid receptor B is functionally down-regulated in isolated lipid raft-enriched membranes. | lld:pubmed |
| pubmed-article:15358124 | pubmed:affiliation | Medical Research Council Anatomical Neuropharmacology Unit, University Department of Pharmacology, University of Oxford, Mansfield Road, Oxford, OX1 3TH, UK. anja.becher@pharm.ox.ac.uk | lld:pubmed |
| pubmed-article:15358124 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15358124 | lld:pubmed |
