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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2004-9-10
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pubmed:abstractText |
We have previously isolated three synthetic lethal mutants from Schizosaccharomyces pombe in order to identify mutations in the genes that are functionally linked to spmex67 with respect to mRNA export. A novel rsm1 gene was isolated by complementation of the growth defect in one of the synthetic lethal mutants, SLMexl. The rsm1 gene contains no introns and encodes a 296 amino-acid-long protein with the RING finger domain, a C3HC4 in the N-terminal half. The deltarsm1 null mutant is viable, but it showed a slight poly(A)+ RNA accumulation in the nucleus. Also, the combination of deltarsm1 and deltaspmex67 mutations confers synthetic lethality that is accompanied by the severe poly(A)+ RNA export defect. These results suggest that rsm1 is involved in mRNA export from the nucleus.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1225-8873
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
42
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
32-6
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pubmed:meshHeading |
pubmed-meshheading:15357289-Biological Transport,
pubmed-meshheading:15357289-Cell Nucleus,
pubmed-meshheading:15357289-Gene Deletion,
pubmed-meshheading:15357289-Genes, Essential,
pubmed-meshheading:15357289-Genes, Fungal,
pubmed-meshheading:15357289-Genes, Lethal,
pubmed-meshheading:15357289-Genetic Complementation Test,
pubmed-meshheading:15357289-Introns,
pubmed-meshheading:15357289-Mutation,
pubmed-meshheading:15357289-Nucleocytoplasmic Transport Proteins,
pubmed-meshheading:15357289-Open Reading Frames,
pubmed-meshheading:15357289-Protein Structure, Tertiary,
pubmed-meshheading:15357289-RNA, Fungal,
pubmed-meshheading:15357289-RNA, Messenger,
pubmed-meshheading:15357289-Schizosaccharomyces,
pubmed-meshheading:15357289-Schizosaccharomyces pombe Proteins
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pubmed:year |
2004
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pubmed:articleTitle |
Schizosaccharomyces pombe rsm1 genetically interacts with spmex67, which is involved in mRNA export.
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pubmed:affiliation |
Division of Biology, College of Natural Sciences, Kangnung National University, Gangneung 210-702, Korea. jhoyoon@kangnung.ac.kr
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pubmed:publicationType |
Journal Article
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