Source:http://linkedlifedata.com/resource/pubmed/id/15356158
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions |
umls-concept:C0021311,
umls-concept:C0023861,
umls-concept:C0025260,
umls-concept:C0039194,
umls-concept:C0085358,
umls-concept:C0205245,
umls-concept:C0851827,
umls-concept:C1332717,
umls-concept:C1413244,
umls-concept:C1527148,
umls-concept:C1539081,
umls-concept:C1701901,
umls-concept:C1706438,
umls-concept:C2698600
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| pubmed:issue |
6
|
| pubmed:dateCreated |
2004-9-9
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| pubmed:abstractText |
The immunologic requirements for generating long-lived protective CD8 T cell memory remain unclear. Memory CD8 populations generated in the absence of CD4 Th cells reportedly have functional defects, and at least a subset of CD8 T cells transiently express CD40 after activation, suggesting that direct CD4-CD8 T cell interactions through CD40 may influence the magnitude and functional quality of memory CD8 populations. To ascertain the role of CD40 in such direct T cell interactions, we investigated CD8 T cell responses in CD40-/- mice after infection with Listeria monocytogenes, an intracellular bacterium that induces APC activation and thus priming of CD8 T cells independently of CD4 Th cell help through CD40. In this study we show that memory CD8 T cells generated in CD40-deficient mice show in vivo cytotoxicity and cytokine production equivalent to CD8 memory T cells from wild-type mice. Upon secondary Listeria infection, CD40-/- memory CD8 T cells expand to greater numbers than seen in wild-type mice. These results indicate that CD40 ligation on CD8 T cells, although reportedly a part of CD8 T cell memory development in an H-Y-directed response, is not needed for the development of functional memory CD8 T cell populations after Listeria infection.
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| pubmed:grant | |
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
AIM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Sep
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| pubmed:issn |
0022-1767
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| pubmed:author | |
| pubmed:copyrightInfo |
Copyright 2004 The American Association of Immunologists, Inc.
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| pubmed:issnType |
Print
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| pubmed:day |
15
|
| pubmed:volume |
173
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
4084-90
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| pubmed:dateRevised |
2010-11-18
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| pubmed:meshHeading |
pubmed-meshheading:15356158-Animals,
pubmed-meshheading:15356158-Antigens, CD40,
pubmed-meshheading:15356158-CD40 Ligand,
pubmed-meshheading:15356158-CD8-Positive T-Lymphocytes,
pubmed-meshheading:15356158-Cell Differentiation,
pubmed-meshheading:15356158-Cell Line, Tumor,
pubmed-meshheading:15356158-Cells, Cultured,
pubmed-meshheading:15356158-Cytokines,
pubmed-meshheading:15356158-Cytotoxicity, Immunologic,
pubmed-meshheading:15356158-Immunization, Secondary,
pubmed-meshheading:15356158-Immunologic Memory,
pubmed-meshheading:15356158-Listeria monocytogenes,
pubmed-meshheading:15356158-Listeriosis,
pubmed-meshheading:15356158-Lymphocyte Activation,
pubmed-meshheading:15356158-Mice,
pubmed-meshheading:15356158-Mice, Inbred BALB C,
pubmed-meshheading:15356158-Mice, Knockout,
pubmed-meshheading:15356158-Signal Transduction
|
| pubmed:year |
2004
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| pubmed:articleTitle |
The development of functional CD8 T cell memory after Listeria monocytogenes infection is not dependent on CD40.
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| pubmed:affiliation |
Department of Molecular Microbiology, Oregon Health and Science University, Portland 97239, USA.
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| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.
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