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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1992-7-29
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pubmed:abstractText |
It has been established that at least some V beta 17+ T cells interact with an endogenous superantigen encoded by the murine retrovirus, Mtv-9. To analyze the role of major histocompatibility complex (MHC) class II molecules in presenting the Mtv-9 encoded superantigen, vSAG-9 to V beta 17+ hybridomas, a panel of nine hybridomas was tested for their ability to respond to A20/2J (H-2d) and LBK (H-2a) cells which had been transfected with the vSAG-9 gene. Whereas some of the hybridomas recognized vSAG-9 exclusively in the context of H-2a, other hybridomas recognized vSAG-9 exclusively in the context of H-2d or in the context of both H-2d and H-2a. These results suggest that: (a) the class II MHC molecule plays a direct role in the recognition of retroviral superantigen by T cells, rather than serving simply as a platform for presentation; and, (b) it is likely that components of the TCR other than V beta are involved in the vSAG-9/TCR/class II interaction.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/1535369-1531997,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1535369-1658187,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1535369-1832875,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1535369-1835267,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1535369-1846949,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1535369-1907996,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1535369-1968289,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1535369-2037017,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1535369-2117633,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1535369-2522086,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1535369-2523951,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1535369-2579127,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1535369-3280471,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1535369-3494522,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1535369-6183199
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0022-1007
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
176
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
275-80
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pubmed:dateRevised |
2010-9-7
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pubmed:meshHeading |
pubmed-meshheading:1535369-Animals,
pubmed-meshheading:1535369-Antigens, Viral,
pubmed-meshheading:1535369-Enterotoxins,
pubmed-meshheading:1535369-Histocompatibility Antigens Class II,
pubmed-meshheading:1535369-Hybridomas,
pubmed-meshheading:1535369-Mice,
pubmed-meshheading:1535369-Mice, Inbred BALB C,
pubmed-meshheading:1535369-Receptors, Antigen, T-Cell, alpha-beta,
pubmed-meshheading:1535369-Retroviridae,
pubmed-meshheading:1535369-T-Lymphocytes
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pubmed:year |
1992
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pubmed:articleTitle |
Major histocompatibility complex-restricted recognition of retroviral superantigens by V beta 17+ T cells.
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pubmed:affiliation |
Department of Immunology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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