Linked Life Data

15353303

Source:http://linkedlifedata.com/resource/pubmed/id/15353303

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2004-9-8
pubmed:abstractText
Interest in neuroprotectants for the central nervous system continues to garner significant attention. Nicotinamide, the amide form of niacin (vitamin B3), is the precursor for the coenzyme beta-nicotinamide adenine dinucleotide (NAD+) and is considered to be necessary for cellular function and metabolism. However, recent work has focused on the development of nicotinamide as a novel agent that is critical for modulating cellular plasticity, longevity, and inflammatory microglial function. The ability of nicotinamide to preserve both neuronal and vascular cell populations in the brain during injury is intriguing, but further knowledge of the specific cellular mechanisms that determine protection by this agent is required. The capacity of nicotinamide to govern not only intrinsic cellular integrity, but also extrinsic cellular inflammation rests with the modulation of a host of cellular targets that involve protein kinase B, glycogen synthase kinase-3 beta (GSK-3 beta), Forkhead transcription factors, mitochondrial dysfunction, poly(ADP-ribose) polymerase, cysteine proteases, and microglial activation. Intimately tied to the cytoprotection of nicotinamide is the modulation of an early and late phase of apoptotic injury that is triggered by the loss of membrane asymmetry. Identifying robust cytoprotective agents as nicotinamide in conjunction with the elucidation of the cellular mechanisms responsible for cell survival will continue to solidify the development of therapeutic strategies against neurodegenerative diseases
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
1093-4715
pubmed:author
pubmed:issnType
Electronic
pubmed:day
1
pubmed:volume
9
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2500-20
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed-meshheading:15353303-Aging, pubmed-meshheading:15353303-Animals, pubmed-meshheading:15353303-Apoptosis, pubmed-meshheading:15353303-Apoptotic Protease-Activating Factor 1, pubmed-meshheading:15353303-Caspases, pubmed-meshheading:15353303-Cell Survival, pubmed-meshheading:15353303-Endothelial Cells, pubmed-meshheading:15353303-Humans, pubmed-meshheading:15353303-Inflammation, pubmed-meshheading:15353303-Intracellular Signaling Peptides and Proteins, pubmed-meshheading:15353303-Mitochondria, pubmed-meshheading:15353303-NAD, pubmed-meshheading:15353303-Neurons, pubmed-meshheading:15353303-Niacinamide, pubmed-meshheading:15353303-Phosphatidylserines, pubmed-meshheading:15353303-Poly(ADP-ribose) Polymerases, pubmed-meshheading:15353303-Proteins, pubmed-meshheading:15353303-Tumor Necrosis Factor-alpha
pubmed:year
2004
pubmed:articleTitle
Navigating novel mechanisms of cellular plasticity with the NAD+ precursor and nutrient nicotinamide.
pubmed:affiliation
Division of Cellular and Molecular Cerebral Ischemia, Institute of Environmental Health Sciences, Wayne State University School of Medicine, Detroit, Michigan 48201, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Review, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural