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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
2004-10-21
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pubmed:abstractText |
Earlier studies have suggested that complexes of the human IgA receptor FcalphaRI/CD89 with mouse IgA are pathogenic upon deposition in the renal mesangium. Transgenic mice expressing FcalphaRI/CD89 on macrophages/monocytes developed massive mesangial IgA deposition and a clinical picture of IgA nephropathy (IgAN). Based on these findings, the purpose of this study was to design an experimental model of IgAN by injection of human CD89 in mice. The interaction of mouse IgA with CD89 was investigated further.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0931-0509
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
19
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2729-36
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:15340093-Animals,
pubmed-meshheading:15340093-Antigens, CD,
pubmed-meshheading:15340093-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:15340093-Flow Cytometry,
pubmed-meshheading:15340093-Glomerular Mesangium,
pubmed-meshheading:15340093-Glomerulonephritis, IGA,
pubmed-meshheading:15340093-Immunoglobulin A,
pubmed-meshheading:15340093-Mice,
pubmed-meshheading:15340093-Mice, Inbred BALB C,
pubmed-meshheading:15340093-Receptors, Fc,
pubmed-meshheading:15340093-Recombinant Proteins
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pubmed:year |
2004
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pubmed:articleTitle |
Injection of recombinant FcalphaRI/CD89 in mice does not induce mesangial IgA deposition.
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pubmed:affiliation |
Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands. p.j.m.van_der_boog@lumc.nl
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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