Linked Life Data

15339009

Source:http://linkedlifedata.com/resource/pubmed/id/15339009

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
2004-9-1
pubmed:databankReference
pubmed:abstractText
Peroxisome proliferatior-activated receptor-gamma (PPARgamma) is a transcription factor that modulates lipid and glucose metabolism in mammals. The aim of the present study was to investigate whether chicken PPARgamma is expressed in tissues in a similar manner to mammalian PPAR and whether it is involved in the regulation of lipid metabolism, particularly in the regulation of fat accumulation in adipose tissue and ovaries. In 30-wk-old chickens, PPARgamma mRNA was detected in most tissues that were examined. Of those tissues expressing chicken PPARgamma mRNA, the lowest expression levels were found in adipose tissue, the tissue that in mammals was shown to express the highest levels of PPARgamma mRNA. Chicken PPARgamma mRNA expression in abdominal adipose tissue tended to increase with age, as shown by higher expression levels at 6 wk than at 1 and 2 wk of age. With regard to nutritional modulation, PPARgamma mRNA levels in abdominal adipose tissue were significantly higher in broiler chickens fed for 7 d a diet containing 8% safflower oil (18:2-rich) or linseed oil (18:3-rich) compared with chickens fed a diet containing olive oil (18:1-rich). In contrast, feeding a 3% cholesterol-supplemented diet for 7 d resulted in no changes to adipose PPARgamma mRNA expression. In broiler chickens orally administered troglitazone, a PPARgamma ligand, abdominal fat pad weight and PPARgamma and lipoprotein lipase (LPL) mRNA levels were significantly increased relative to those of control chickens. Levels of PPARgamma mRNA in liver, skeletal muscle, and ovaries were increased with the onset of egg laying, whereas in adipose tissue the level of PPARgamma mRNA was decreased. These findings suggest that PPARgamma plays an important role in the regulation of fat deposition and egg production and the characteristic pattern of PPARgamma mRNA expression may be indicative of specific differences in the lipid and glucose metabolism of chickens compared with mammals.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0032-5791
pubmed:author
pubmed:issnType
Print
pubmed:volume
83
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1342-7
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed-meshheading:15339009-Abdomen, pubmed-meshheading:15339009-Adipose Tissue, pubmed-meshheading:15339009-Aging, pubmed-meshheading:15339009-Animal Nutritional Physiological Phenomena, pubmed-meshheading:15339009-Animals, pubmed-meshheading:15339009-Chickens, pubmed-meshheading:15339009-Cholesterol, Dietary, pubmed-meshheading:15339009-Dietary Fats, Unsaturated, pubmed-meshheading:15339009-Female, pubmed-meshheading:15339009-Gene Expression, pubmed-meshheading:15339009-Linseed Oil, pubmed-meshheading:15339009-Liver, pubmed-meshheading:15339009-Male, pubmed-meshheading:15339009-Molecular Sequence Data, pubmed-meshheading:15339009-Muscle, Skeletal, pubmed-meshheading:15339009-Organ Specificity, pubmed-meshheading:15339009-Ovary, pubmed-meshheading:15339009-Oviposition, pubmed-meshheading:15339009-Plant Oils, pubmed-meshheading:15339009-RNA, Messenger, pubmed-meshheading:15339009-Receptors, Cytoplasmic and Nuclear, pubmed-meshheading:15339009-Safflower Oil, pubmed-meshheading:15339009-Transcription Factors
pubmed:year
2004
pubmed:articleTitle
Expression of the chicken peroxisome proliferator-activated receptor-gamma gene is influenced by aging, nutrition, and agonist administration.
pubmed:affiliation
Animal Nutrition, Graduate School of Agricultural Science, Tohoku University, Sendai, Japan 981-8555.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't