15327099

Source:http://linkedlifedata.com/resource/pubmed/id/15327099

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0020792, umls-concept:C0205210, umls-concept:C0346388, umls-concept:C1521761
pubmed:issue	4
pubmed:dateCreated	2004-8-25
pubmed:abstractText	The detection and treatment of choroidal melanoma early in its natural course is critical to providing the patient with the best prognosis. Studies of tumour doubling time have indicated that metastasis from choroidal melanoma can occur quite early in the course of the disease, when the tumour is about 3.0 mm in basal dimension and 1.5 mm in thickness. Clinical studies have shown that, at 5 years, metastasis occurs in 16% of patients with small choroidal melanomas (less than 4 mm thick), compared with 32% of those with medium-sized (4-8 mm thick) choroidal melanomas and 53% of those with large (more than 8 mm thick) choroidal melanomas. The difficulty with early detection of choroidal melanoma relates to its clinical similarity to benign choroidal nevus. Factors that assist in differentiating small choroidal melanoma from choroidal nevus can be remembered using the mnemonic "TFSOM" (to find small ocular melanoma), where T = thickness greater than 2 mm, F = subretinal fluid, S = symptoms, O = orange pigment and M = margin touching optic disc. Choroidal melanocytic tumours that display none of these factors have a 3% risk of growth into melanoma at 5 years and most likely represent choroidal nevi. Tumours that display one factor have a 38% risk of growth, and those with two or more factors show growth in over 50% of cases. Most tumours with two or more risk factors probably represent small choroidal melanomas, and early treatment is generally indicated. Therefore, ophthalmologists should be aware of the clinical factors that identify small choroidal melanoma so that early treatment and better prognosis can be achieved for their patients.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/0045312
pubmed:citationSubset	IM
pubmed:status	MEDLINE
pubmed:month	Jun
pubmed:issn	0008-4182
pubmed:author	pubmed-author:DemirciHakanH, pubmed-author:MarrBrian PBP, pubmed-author:MashayekhiArmanA, pubmed-author:MaterinMiguel AMA, pubmed-author:ShieldsCarol LCL, pubmed-author:ShieldsJerry AJA
pubmed:issnType	Print
pubmed:volume	39
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	351-7
pubmed:dateRevised	2009-11-3
pubmed:meshHeading	pubmed-meshheading:15327099-Choroid Neoplasms, pubmed-meshheading:15327099-Humans, pubmed-meshheading:15327099-Melanoma
pubmed:year	2004
pubmed:articleTitle	Clinical factors in the identification of small choroidal melanoma.
pubmed:affiliation	Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, PA 19107, USA. carol.shields@shieldsoncology.com
pubmed:publicationType	Journal Article, Review, Research Support, Non-U.S. Gov't