Linked Life Data

15325380

Source:http://linkedlifedata.com/resource/pubmed/id/15325380

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2004-8-24
pubmed:abstractText
We used magnetic resonance imaging (MRI) and cortical pattern matching to map differences in cortical gray matter deficits between Alzheimer's disease (AD) and dementia with Lewy bodies (DLB), and explored the possible influence of gender on these patterns. Twenty-nine patients with AD (age 77.9 +/- 5.5), 16 patients with DLB (76.4 +/- 6.7), and 38 controls (75.3 +/- 6.8) were included. Dementia groups were matched for illness severity. Detailed spatial analyses of gray matter were conducted across the entire cerebral cortex by measuring local proportions of gray matter at thousands of homologous cortical surface locations in each subject and between diagnostic groups. To visualize regional changes, statistical differences were mapped at each cortical surface location in 3D. Main effects of diagnosis demonstrated prominent gray matter differences in orbitofrontal and temporal cortices, where AD exhibited the greatest deficits relative to DLB. Main effects of sex showed less gray matter in men within all group comparisons. Exploratory findings for sex by diagnosis interactions suggest greater gray matter loss in the anterior cingulate for men with AD, relative to controls, AD females, and individuals with DLB. Relative preservation of orbitofrontal cortices in addition to temporal structures may contribute to distinguishing DLB from AD. Further investigation of the influence of gender might provide a more comprehensive understanding of the pathophysiological differences underlying the two forms of dementia.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
1053-8119
pubmed:author
pubmed:issnType
Print
pubmed:volume
23
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
325-35
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed-meshheading:15325380-Aged, pubmed-meshheading:15325380-Aged, 80 and over, pubmed-meshheading:15325380-Alzheimer Disease, pubmed-meshheading:15325380-Atrophy, pubmed-meshheading:15325380-Brain Mapping, pubmed-meshheading:15325380-Cerebral Cortex, pubmed-meshheading:15325380-Diagnosis, Differential, pubmed-meshheading:15325380-Dominance, Cerebral, pubmed-meshheading:15325380-Frontal Lobe, pubmed-meshheading:15325380-Gyrus Cinguli, pubmed-meshheading:15325380-Humans, pubmed-meshheading:15325380-Image Processing, Computer-Assisted, pubmed-meshheading:15325380-Imaging, Three-Dimensional, pubmed-meshheading:15325380-Lewy Body Disease, pubmed-meshheading:15325380-Magnetic Resonance Imaging, pubmed-meshheading:15325380-Mathematical Computing, pubmed-meshheading:15325380-Middle Aged, pubmed-meshheading:15325380-Reference Values, pubmed-meshheading:15325380-Sex Factors, pubmed-meshheading:15325380-Temporal Lobe
pubmed:year
2004
pubmed:articleTitle
Comparing gray matter loss profiles between dementia with Lewy bodies and Alzheimer's disease using cortical pattern matching: diagnosis and gender effects.
pubmed:affiliation
Laboratory of NeuroImaging, Department of Neurology, David Geffen UCLA School of Medicine, Los Angeles, CA 90095-1769, USA.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't