Source:http://linkedlifedata.com/resource/pubmed/id/15319855
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
|
| pubmed:dateCreated |
2004-8-20
|
| pubmed:abstractText |
To investigate transmission of human herpesvirus (HHV)-8, 2546 mother-child pairs were recruited from rural clinics in South Africa and were tested for antibodies against lytic and latent HHV-8 antigens. The prevalence of antibodies in children increased with increasing maternal antibody titer (lytic, chi 21=26, and P<.001; latent, chi 21=55, and P<.001). HHV-8 DNA was detectable in 145 of 978 maternal saliva samples (mean virus load, 488,450 copies/mL; range, 1550-660,000 copies/mL) and in 12 of 43 breast-milk samples (mean virus load, 5800 copies/mL; range, 1550-12,540 copies/mL). The prevalence of HHV-8 DNA in maternal saliva was unrelated to latent anti-HHV-8 antibody status but was higher in mothers with the highest titers of lytic antibodies than in other mothers (34% vs. 8%; P<.001). The prevalence of lytic anti-HHV-8 antibodies in children was 13% (70/528) if the mother did not have HHV-8 in saliva and was 29% (8/28) if the mother had a high HHV-8 load (>50,000 copies/mL) in saliva (odds ratio, 2.6; 95% confidence interval, 1.1-6.2). The presence of HHV-8 DNA in maternal saliva was unrelated to latent antibodies in children. Saliva could be a route of transmission of HHV-8 from person to person, although other routes cannot be ruled out.
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| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Sep
|
| pubmed:issn |
0022-1899
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| pubmed:author |
pubmed-author:AlkharsahKhaled RKR,
pubmed-author:CasabonneDelphineD,
pubmed-author:CassolSharon ASA,
pubmed-author:DedicoatMartinM,
pubmed-author:GilksCharles FCF,
pubmed-author:NdlovuBukekileB,
pubmed-author:NewtonRobertR,
pubmed-author:PageTarynT,
pubmed-author:SchulzThomas FTF,
pubmed-author:SheldonJulieJ,
pubmed-author:SzabadosIldikoI,
pubmed-author:WhitbyDeniseD
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| pubmed:issnType |
Print
|
| pubmed:day |
15
|
| pubmed:volume |
190
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1068-75
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| pubmed:dateRevised |
2008-11-21
|
| pubmed:meshHeading |
pubmed-meshheading:15319855-Adolescent,
pubmed-meshheading:15319855-Adult,
pubmed-meshheading:15319855-Antibodies, Viral,
pubmed-meshheading:15319855-Antigens, Viral,
pubmed-meshheading:15319855-Case-Control Studies,
pubmed-meshheading:15319855-Child, Preschool,
pubmed-meshheading:15319855-DNA, Viral,
pubmed-meshheading:15319855-Female,
pubmed-meshheading:15319855-HIV Antibodies,
pubmed-meshheading:15319855-Herpesviridae Infections,
pubmed-meshheading:15319855-Herpesvirus 8, Human,
pubmed-meshheading:15319855-Humans,
pubmed-meshheading:15319855-Infant,
pubmed-meshheading:15319855-Infant, Newborn,
pubmed-meshheading:15319855-Infectious Disease Transmission, Vertical,
pubmed-meshheading:15319855-Milk, Human,
pubmed-meshheading:15319855-Saliva,
pubmed-meshheading:15319855-South Africa
|
| pubmed:year |
2004
|
| pubmed:articleTitle |
Mother-to-child transmission of human herpesvirus-8 in South Africa.
|
| pubmed:affiliation |
Liverpool School of Tropical Medicine, Liverpool, and Cancer Research UK Epidemiology Unit, Oxford, United Kingdom. martded@aol.com
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|