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rdf:type |
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lifeskim:mentions |
umls-concept:C0010453,
umls-concept:C0020564,
umls-concept:C0021289,
umls-concept:C0030054,
umls-concept:C0034693,
umls-concept:C0034721,
umls-concept:C0205263,
umls-concept:C0225828,
umls-concept:C0299583,
umls-concept:C1704259,
umls-concept:C1705920,
umls-concept:C1705987
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pubmed:issue |
10
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pubmed:dateCreated |
2004-9-8
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pubmed:abstractText |
Obesity is a major risk factor for the development of cardiovascular disease. Emerging evidence indicates that leptin, a protein encoded by the obesity gene, is linked with cardiac hypertrophy in obese humans and directly induces cardiomyocyte hypertrophy in vitro. However, the mechanisms by which leptin induces cardiomyocyte hypertrophy are poorly understood.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/A 127722,
http://linkedlifedata.com/resource/pubmed/chemical/Antioxidants,
http://linkedlifedata.com/resource/pubmed/chemical/Atrial Natriuretic Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Catalase,
http://linkedlifedata.com/resource/pubmed/chemical/Endothelin-1,
http://linkedlifedata.com/resource/pubmed/chemical/Leptin,
http://linkedlifedata.com/resource/pubmed/chemical/Pyrrolidines,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Reactive Oxygen Species,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Endothelin A
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1524-4539
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
7
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pubmed:volume |
110
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1269-75
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:15313952-Animals,
pubmed-meshheading:15313952-Animals, Newborn,
pubmed-meshheading:15313952-Antioxidants,
pubmed-meshheading:15313952-Atrial Natriuretic Factor,
pubmed-meshheading:15313952-Cardiomegaly,
pubmed-meshheading:15313952-Catalase,
pubmed-meshheading:15313952-Cell Size,
pubmed-meshheading:15313952-Cells, Cultured,
pubmed-meshheading:15313952-Endothelin-1,
pubmed-meshheading:15313952-Gene Expression Regulation,
pubmed-meshheading:15313952-Leptin,
pubmed-meshheading:15313952-Myocytes, Cardiac,
pubmed-meshheading:15313952-Obesity,
pubmed-meshheading:15313952-Oxidative Stress,
pubmed-meshheading:15313952-Pyrrolidines,
pubmed-meshheading:15313952-RNA, Messenger,
pubmed-meshheading:15313952-Rats,
pubmed-meshheading:15313952-Rats, Sprague-Dawley,
pubmed-meshheading:15313952-Reactive Oxygen Species,
pubmed-meshheading:15313952-Receptor, Endothelin A,
pubmed-meshheading:15313952-Reverse Transcriptase Polymerase Chain Reaction
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pubmed:year |
2004
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pubmed:articleTitle |
Leptin induces hypertrophy via endothelin-1-reactive oxygen species pathway in cultured neonatal rat cardiomyocytes.
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pubmed:affiliation |
Department of Pharmacology, Guangzhou Medical College, Guangzhou, China 510182.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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