15313047

Source:http://linkedlifedata.com/resource/pubmed/id/15313047

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0003467, umls-concept:C0004927, umls-concept:C0013126, umls-concept:C0022885, umls-concept:C0026809, umls-concept:C0079904, umls-concept:C0392366, umls-concept:C0392756
pubmed:issue	2
pubmed:dateCreated	2004-8-17
pubmed:abstractText	The ubiquitous transcription factor nuclear factor (NF)-kappaB plays a prominent role in regulation of inflammatory immune responses and in cell survival. Recently, it has been found to be active in neurons, and mice lacking NF-kappaB subunits p50 or p65 show deficits in specific cognitive tasks. Here we demonstrate a strikingly low level of anxiety-like behavior in the p50(-/-) mouse. In an open field, the mutant mice showed significantly less defecation, more rearing, and more time spent in the center compartment relative to wild type control mice. The p50(-/-) mice also spent more time investigating a novel object placed in the open field. On the elevated plus maze, p50(-/-) mice spent more time on the open arms and had increased numbers of open arm entries relative to wild type. In group housing conditions, they did not establish dominant-subordinate hierarchies, whereas wild type control animals did so, in part, by whisker barbering and conspecific allogrooming. In tests of general health, sensorimotor function, and daily activity on a circadian rhythm, p50(-/-) mice were normal. Thus, absence of the p50 subunit of the NF-kappaB transcription factor, which results in altered NF-kappaB transcriptional activity in cells throughout the body and brain, alters neuronal circuitry underlying manifestation of emotional behavior. The p50 subunit appears to play a role in normal expression of certain forms of anxiety.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/8004872
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/NF-kappa B, http://linkedlifedata.com/resource/pubmed/chemical/NF-kappa B p50 Subunit
pubmed:status	MEDLINE
pubmed:month	Oct
pubmed:issn	0166-4328
pubmed:author	pubmed-author:HerkenhamMilesM, pubmed-author:KassedCheryl ACA
pubmed:issnType	Print
pubmed:day	5
pubmed:volume	154
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	577-84
pubmed:dateRevised	2006-11-15
pubmed:meshHeading	pubmed-meshheading:15313047-Animals, pubmed-meshheading:15313047-Anxiety, pubmed-meshheading:15313047-Behavior, Animal, pubmed-meshheading:15313047-Circadian Rhythm, pubmed-meshheading:15313047-Drive, pubmed-meshheading:15313047-Exploratory Behavior, pubmed-meshheading:15313047-Gene Expression Regulation, pubmed-meshheading:15313047-Habituation, Psychophysiologic, pubmed-meshheading:15313047-Male, pubmed-meshheading:15313047-Maze Learning, pubmed-meshheading:15313047-Mice, pubmed-meshheading:15313047-Mice, Knockout, pubmed-meshheading:15313047-Motor Activity, pubmed-meshheading:15313047-NF-kappa B, pubmed-meshheading:15313047-NF-kappa B p50 Subunit, pubmed-meshheading:15313047-Psychomotor Performance, pubmed-meshheading:15313047-Statistics, Nonparametric, pubmed-meshheading:15313047-Time Factors
pubmed:year	2004
pubmed:articleTitle	NF-kappaB p50-deficient mice show reduced anxiety-like behaviors in tests of exploratory drive and anxiety.
pubmed:affiliation	Section on Functional Neuroanatomy, National Institute of Mental Health, NIH, DHHS, Bldg. 36, Rm. 2D15, Bethesda, MD 20892-4070, USA.
pubmed:publicationType	Journal Article, Comparative Study, Research Support, U.S. Gov't, P.H.S.