rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2004-8-12
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pubmed:abstractText |
The increase of the 14-3-3 protein in CSF is used as a diagnostic test in Creutzfeldt-Jakob disease (CJD), but the sensitivity and specificity of the 14-3-3 test are disputed. One reason for the dispute may be the recently established heterogeneity of sporadic CJD. The relationship between CSF 14-3-3 protein and sporadic CJD subtypes, distinguished by electrophoretic mobility of proteinase K-resistant prion protein (PrP(Sc)) and genotype at codon 129 of the prion protein gene, has not been elucidated.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1526-632X
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pubmed:author |
pubmed-author:CapellariSS,
pubmed-author:CastellaniR JRJ,
pubmed-author:ChenS GSG,
pubmed-author:ColucciMM,
pubmed-author:GambettiPP,
pubmed-author:LiZ PZP,
pubmed-author:MAJJ,
pubmed-author:ParchiPP,
pubmed-author:PastoreMM,
pubmed-author:RahbarM HMH,
pubmed-author:XieZZ
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pubmed:issnType |
Electronic
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pubmed:day |
10
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pubmed:volume |
63
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
436-42
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:15304573-14-3-3 Proteins,
pubmed-meshheading:15304573-Aged,
pubmed-meshheading:15304573-Amyloid,
pubmed-meshheading:15304573-Biological Markers,
pubmed-meshheading:15304573-Codon,
pubmed-meshheading:15304573-Creutzfeldt-Jakob Syndrome,
pubmed-meshheading:15304573-Female,
pubmed-meshheading:15304573-Genotype,
pubmed-meshheading:15304573-Humans,
pubmed-meshheading:15304573-Male,
pubmed-meshheading:15304573-Middle Aged,
pubmed-meshheading:15304573-Neocortex,
pubmed-meshheading:15304573-Phenotype,
pubmed-meshheading:15304573-PrPSc Proteins,
pubmed-meshheading:15304573-Prions,
pubmed-meshheading:15304573-Protein Precursors,
pubmed-meshheading:15304573-Sensitivity and Specificity
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pubmed:year |
2004
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pubmed:articleTitle |
Sensitivity of 14-3-3 protein test varies in subtypes of sporadic Creutzfeldt-Jakob disease.
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pubmed:affiliation |
National Prion Disease Pathology Surveillance Center, Division of Neuropathology, Institute of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't,
Evaluation Studies
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