Linked Life Data

15303408

Source:http://linkedlifedata.com/resource/pubmed/id/15303408

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
2004-8-11
pubmed:abstractText
In this study, we investigate the polymorphic microsatellite repeat (TCAT)n, in the insulin gene region that has been associated with susceptibility to type-1 diabetes in some Caucasian populations. The microsatellite repeat polymorphism begins at base pair 1,170 in intron 1 of the hTH gene, which is located on the short arm of chromosome 11. This study is the first to investigate the association of this microsatellite repeat polymorphism in African-American type-1 diabetes patients and controls. The predicted amplified sequence was 254 bp. We found five alleles among African Americans in the Washington, DC area. The alleles were labeled K5 (244 bp), K4 (248 bp), K3 (252 bp), K2 (256 bp), and K1 (260 bp), and heterozygosity was greater than 0.75. The most frequent allele of the hTH microsatellite repeats was K5 (248 bp) with a frequency 0.62 in controls and 0.66 in type-1 diabetes patients, which did not differ significantly. Although the largest allele was more frequent in controls, the difference was not statistically significant. The five alleles of the hTH microsatellite generated 15 different genotypes. The most frequent genotype in controls and patients was K5/K4, whose frequencies were 0.19 and 0.17, respectively. No significant differences in genotype frequencies were found between type-1 diabetes patients and controls. This data shifts the focus from hTH to the VNTR at the insulin gene for IDDM2, the second major candidate gene for type-1 diabetes.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/15303408-11532988, http://linkedlifedata.com/resource/pubmed/commentcorrection/15303408-1574802, http://linkedlifedata.com/resource/pubmed/commentcorrection/15303408-1677184, http://linkedlifedata.com/resource/pubmed/commentcorrection/15303408-2218721, http://linkedlifedata.com/resource/pubmed/commentcorrection/15303408-2295091, http://linkedlifedata.com/resource/pubmed/commentcorrection/15303408-2872999, http://linkedlifedata.com/resource/pubmed/commentcorrection/15303408-2882428, http://linkedlifedata.com/resource/pubmed/commentcorrection/15303408-2902075, http://linkedlifedata.com/resource/pubmed/commentcorrection/15303408-4401209, http://linkedlifedata.com/resource/pubmed/commentcorrection/15303408-7909987, http://linkedlifedata.com/resource/pubmed/commentcorrection/15303408-8036515, http://linkedlifedata.com/resource/pubmed/commentcorrection/15303408-9013043, http://linkedlifedata.com/resource/pubmed/commentcorrection/15303408-9055609, http://linkedlifedata.com/resource/pubmed/commentcorrection/15303408-9084894, http://linkedlifedata.com/resource/pubmed/commentcorrection/15303408-9466999
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0027-9684
pubmed:author
pubmed:issnType
Print
pubmed:volume
96
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1042-6
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed:year
2004
pubmed:articleTitle
IDDM2 and the polymorphism of the human tyrosine hydroxylase (hTH) gene in African Americans with type-1 diabetes.
pubmed:affiliation
Immunogenetics Laboratory, and Department of Pediatrics, Howard University Hospital, Washington, DC, USA. Noureddine.Berka@cls.ab.ca
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.