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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
15
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pubmed:dateCreated |
2004-8-6
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pubmed:abstractText |
Ovarian carcinoma is a highly lethal malignancy that often becomes resistant to chemotherapy. Alterations in apoptotic signals and p53 status contribute to drug resistance, and CD95-mediated apoptosis is also deficient in resistant cells. We analyzed the mechanism of resistance to CD95-mediated apoptosis in ovarian carcinoma cell lines differing in p53 status.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD95,
http://linkedlifedata.com/resource/pubmed/chemical/CASP8 and FADD-Like Apoptosis...,
http://linkedlifedata.com/resource/pubmed/chemical/CASP8 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/CFLAR protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Caspase 8,
http://linkedlifedata.com/resource/pubmed/chemical/Caspases,
http://linkedlifedata.com/resource/pubmed/chemical/Cycloheximide,
http://linkedlifedata.com/resource/pubmed/chemical/Cytochromes c,
http://linkedlifedata.com/resource/pubmed/chemical/Intracellular Signaling Peptides...,
http://linkedlifedata.com/resource/pubmed/chemical/Oligonucleotides, Antisense,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Synthesis Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Suppressor Protein p53
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1078-0432
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pubmed:author |
pubmed-author:AlbertiPaolaP,
pubmed-author:BagnoliMarinaM,
pubmed-author:BalladoreEmanuelaE,
pubmed-author:CanevariSilvanaS,
pubmed-author:FiginiMariangelaM,
pubmed-author:LuisonElenaE,
pubmed-author:MazzoniAlessandraA,
pubmed-author:MezzanzanicaDeliaD,
pubmed-author:OggionniMariaM,
pubmed-author:PilottiSilvanaS,
pubmed-author:RaspagliesiFrancescoF,
pubmed-author:TurattiFabioF
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
10
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
5202-14
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:15297424-Antigens, CD95,
pubmed-meshheading:15297424-Apoptosis,
pubmed-meshheading:15297424-Blotting, Western,
pubmed-meshheading:15297424-CASP8 and FADD-Like Apoptosis Regulating Protein,
pubmed-meshheading:15297424-Caspase 8,
pubmed-meshheading:15297424-Caspases,
pubmed-meshheading:15297424-Cell Death,
pubmed-meshheading:15297424-Cell Line, Tumor,
pubmed-meshheading:15297424-Cycloheximide,
pubmed-meshheading:15297424-Cytochromes c,
pubmed-meshheading:15297424-DNA Fragmentation,
pubmed-meshheading:15297424-Down-Regulation,
pubmed-meshheading:15297424-Drug Resistance,
pubmed-meshheading:15297424-Enzyme Activation,
pubmed-meshheading:15297424-Female,
pubmed-meshheading:15297424-Flow Cytometry,
pubmed-meshheading:15297424-Humans,
pubmed-meshheading:15297424-Immunohistochemistry,
pubmed-meshheading:15297424-Immunoprecipitation,
pubmed-meshheading:15297424-Intracellular Signaling Peptides and Proteins,
pubmed-meshheading:15297424-Lymphocytes,
pubmed-meshheading:15297424-Mitochondria,
pubmed-meshheading:15297424-Oligonucleotides, Antisense,
pubmed-meshheading:15297424-Ovarian Neoplasms,
pubmed-meshheading:15297424-Protein Synthesis Inhibitors,
pubmed-meshheading:15297424-Subcellular Fractions,
pubmed-meshheading:15297424-Time Factors,
pubmed-meshheading:15297424-Transfection,
pubmed-meshheading:15297424-Tumor Suppressor Protein p53
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pubmed:year |
2004
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pubmed:articleTitle |
CD95-mediated apoptosis is impaired at receptor level by cellular FLICE-inhibitory protein (long form) in wild-type p53 human ovarian carcinoma.
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pubmed:affiliation |
Unit of Molecular Therapies, Department of Experimental Oncology, Istituto Nazionale Tumori, Milan, Italy. delia.mezzanzanica@istitutotumori.mi.it
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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