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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
18
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pubmed:dateCreated |
1992-10-22
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pubmed:databankReference |
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pubmed:abstractText |
An important family of regulatory molecules is made up of proteins that possess the DNA-binding and dimerization motif known as the basic helix-loop-helix (bHLH) domain. The bHLH family includes subgroups of closely related proteins that share common functional properties and overlapping patterns of expression (e.g., the MyoD1 and achaete-scute subgroups). In this report we describe HEN1 and HEN2, mammalian genes that encode a distinct subgroup of bHLH proteins. The HEN1 gene was identified on the basis of cross-hybridization with TAL1, a known bHLH gene implicated in T-cell acute lymphoblastic leukemia. In situ fluorescence hybridization was used to localize the human HEN1 gene to chromosome band 1q22. HEN1 and HEN2 are coexpressed in the IMR-32 human neuroblastoma cell line, and they encode highly related proteins of 133 and 135 residues, respectively, that share 98% amino acid identity in their hHLH domains. These data imply that the bHLH protein subgroup encoded by HEN1 and HEN2 may serve important regulatory functions in the developing nervous system.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/1528853-1729708,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1528853-1763056,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1528853-1846704,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1528853-1886719,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1528853-1915272,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1528853-1934065,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1528853-1964581,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1528853-2006410,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1528853-2038315,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1528853-2069231,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1528853-2105528,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1528853-2174572,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1528853-2209547,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1528853-2251277,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1528853-2253873,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1528853-2303035,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1528853-2392153,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1528853-2461300,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1528853-2493990,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1528853-2503252,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1528853-2536065,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1528853-2602361,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1528853-2740341,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1528853-2752424,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1528853-2971534,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1528853-3111716,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1528853-3290049,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1528853-3400641,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1528853-3607875,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1528853-5459762
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
89
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
8492-6
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pubmed:dateRevised |
2010-9-7
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pubmed:meshHeading |
pubmed-meshheading:1528853-Amino Acid Sequence,
pubmed-meshheading:1528853-Animals,
pubmed-meshheading:1528853-Base Sequence,
pubmed-meshheading:1528853-Basic Helix-Loop-Helix Transcription Factors,
pubmed-meshheading:1528853-Chromosome Mapping,
pubmed-meshheading:1528853-Chromosomes, Human, Pair 1,
pubmed-meshheading:1528853-Cloning, Molecular,
pubmed-meshheading:1528853-DNA-Binding Proteins,
pubmed-meshheading:1528853-Gene Expression,
pubmed-meshheading:1528853-Genes,
pubmed-meshheading:1528853-Humans,
pubmed-meshheading:1528853-Mice,
pubmed-meshheading:1528853-Molecular Sequence Data,
pubmed-meshheading:1528853-Neuroblastoma,
pubmed-meshheading:1528853-Neurons,
pubmed-meshheading:1528853-RNA, Messenger,
pubmed-meshheading:1528853-RNA, Neoplasm,
pubmed-meshheading:1528853-Restriction Mapping,
pubmed-meshheading:1528853-Sequence Alignment,
pubmed-meshheading:1528853-Tumor Cells, Cultured
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pubmed:year |
1992
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pubmed:articleTitle |
HEN1 and HEN2: a subgroup of basic helix-loop-helix genes that are coexpressed in a human neuroblastoma.
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pubmed:affiliation |
Department of Microbiology, University of Texas Southwestern Medical Center, Dallas 75235.
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pubmed:publicationType |
Journal Article,
Comparative Study,
In Vitro,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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