Linked Life Data

15286035

Source:http://linkedlifedata.com/resource/pubmed/id/15286035

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2004-11-23
pubmed:abstractText
Prenatal exposure to environmental chemicals that interfere with the androgen signaling pathway can cause permanent adverse effects on reproductive development in male rats. The objectives of this study were to 1) determine whether a documented antiandrogen butyl benzyl phthalate (BBP) and/or linuron (an androgen receptor antagonist) would decrease fetal testosterone (T) production, 2) describe reproductive developmental effects of linuron and BBP in the male, 3) examine the potential cumulative effects of linuron and BBP, and 4) investigate whether treatment-induced changes to neonatal anogenital distance (AGD) and juvenile areola number were predictive of adult reproductive alterations. Pregnant rats were treated with either corn oil, 75 mg/kg/day of linuron, 500 mg/kg/day of BBP, or a combination of 75 mg/kg/day linuron and 500 mg/kg/day BBP from gestational Day 14 to 18. A cohort of fetuses was removed to assess male testicular T and progesterone production, testicular T concentrations, and whole-body T concentrations. Male offspring from the remaining litters were assessed for AGD and number of areolae and then examined for alterations as young adults. Prenatal exposure to either linuron or BBP or BBP + linuron decreased T production and caused alterations to androgen-organized tissues in a dose-additive manner. Furthermore, treatment-related changes to neonatal AGD and infant areolae significantly correlated with adult AGD, nipple retention, reproductive malformations, and reproductive organ and tissue weights. In general, consideration of the dose-response curves for the antiandrogenic effects suggests that these responses were dose additive rather than synergistic responses. Taken together, these data provide additional evidence of cumulative effects of antiandrogen mixtures on male reproductive development.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0006-3363
pubmed:author
pubmed:issnType
Print
pubmed:volume
71
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1852-61
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:15286035-Anal Canal, pubmed-meshheading:15286035-Androgen Antagonists, pubmed-meshheading:15286035-Animals, pubmed-meshheading:15286035-Animals, Newborn, pubmed-meshheading:15286035-Dose-Response Relationship, Drug, pubmed-meshheading:15286035-Female, pubmed-meshheading:15286035-Fetus, pubmed-meshheading:15286035-Genitalia, Male, pubmed-meshheading:15286035-Linuron, pubmed-meshheading:15286035-Male, pubmed-meshheading:15286035-Osmolar Concentration, pubmed-meshheading:15286035-Phthalic Acids, pubmed-meshheading:15286035-Pregnancy, pubmed-meshheading:15286035-Prenatal Exposure Delayed Effects, pubmed-meshheading:15286035-Progesterone, pubmed-meshheading:15286035-Rats, pubmed-meshheading:15286035-Rats, Sprague-Dawley, pubmed-meshheading:15286035-Sex Differentiation, pubmed-meshheading:15286035-Testis, pubmed-meshheading:15286035-Testosterone
pubmed:year
2004
pubmed:articleTitle
A mixture of the "antiandrogens" linuron and butyl benzyl phthalate alters sexual differentiation of the male rat in a cumulative fashion.
pubmed:affiliation
Deparment of Zoology, North Carolina State University, Raleigh, North Carolina 27695, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, Non-U.S. Gov't