Linked Life Data

15283448

Source:http://linkedlifedata.com/resource/pubmed/id/15283448

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2004-7-30
pubmed:abstractText
A novel animal model of osteoarthritis has been established for studies on the disease process as well as on mechanisms underlying the symptoms of osteoarthritis, principally pain and fatigue. The model is established by cutting the anterior cruciate ligament in the rat to introduce instability of the joint, removing the medial meniscus to induce further derangement of the joint, and exercising the rat on a modified rota-rod to generate weight-bearing mobility of the joint; this exercise can be regulated in terms of duration to govern severity of the model. The model exhibits many of the characteristics of osteoarthritis in humans, including bone and cartilage remodelling, infiltration of the joint tissues by immune cells and alterations in sensory mechanisms. This model will find application in development of novel interventions for the treatment of osteoarthritis and its symptoms as well as development of diagnostic tools for early detection.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:issn
1528-2511
pubmed:author
pubmed:issnType
Print
pubmed:volume
260
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
139-45; discussion 145-53, 277-9
pubmed:dateRevised
2010-4-29
pubmed:meshHeading
pubmed:year
2004
pubmed:articleTitle
Molecular events of chronic pain: from neuron to whole animal in an animal model of osteoarthritis.
pubmed:affiliation
Department of Physiology and Pharmacology, Medical Sciences Building, University of Western Ontario, London, Ontario, N6A 5C1, Canada.
pubmed:publicationType
Journal Article, Review