| pubmed-article:15279899 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15279899 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:15279899 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:15279899 | lifeskim:mentions | umls-concept:C0007137 | lld:lifeskim |
| pubmed-article:15279899 | lifeskim:mentions | umls-concept:C0162638 | lld:lifeskim |
| pubmed-article:15279899 | lifeskim:mentions | umls-concept:C0442027 | lld:lifeskim |
| pubmed-article:15279899 | lifeskim:mentions | umls-concept:C0030956 | lld:lifeskim |
| pubmed-article:15279899 | lifeskim:mentions | umls-concept:C1413106 | lld:lifeskim |
| pubmed-article:15279899 | lifeskim:mentions | umls-concept:C1514562 | lld:lifeskim |
| pubmed-article:15279899 | lifeskim:mentions | umls-concept:C1883221 | lld:lifeskim |
| pubmed-article:15279899 | lifeskim:mentions | umls-concept:C1136254 | lld:lifeskim |
| pubmed-article:15279899 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:15279899 | lifeskim:mentions | umls-concept:C1883204 | lld:lifeskim |
| pubmed-article:15279899 | lifeskim:mentions | umls-concept:C1880389 | lld:lifeskim |
| pubmed-article:15279899 | lifeskim:mentions | umls-concept:C1707271 | lld:lifeskim |
| pubmed-article:15279899 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:15279899 | pubmed:dateCreated | 2004-7-28 | lld:pubmed |
| pubmed-article:15279899 | pubmed:abstractText | Mammalian myeloid and epithelial cells express many antimicrobiotic peptides that contribute to innate host defense against invading microbes. In the present study, a 27-mer peptide of the C-terminal domain (hCAP18(109-135)) and analogs of the antimicrobial peptide human cathelicidin LL-37/human cationic antimicrobial protein 18 (hCAP18) were examined for tumoricidal activity. In vitro results showed that hCAP18(109-135) induced apoptosis in human oral squamous cell carcinoma (OSCC), SAS-H1 cells. The hCAP18(109-135) induced mitochondrial depolarization and apoptosis in SAS-H1 cells, but not in healthy human gingival fibroblasts (HGF) and human keratinocyte line HaCaT cells. Caspases were not activated during hCAP18(109-135)-induced apoptosis in SAS-H1 cells. The results indicate that hCAP18(109-135) may induce caspase-independent apoptosis in OSCC but not in normal cells. hCAP18(109-135) can therefore be a useful anti-tumor therapeutic agent in the treatment of OSCC. | lld:pubmed |
| pubmed-article:15279899 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15279899 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15279899 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15279899 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15279899 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15279899 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15279899 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15279899 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15279899 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15279899 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15279899 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15279899 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15279899 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15279899 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15279899 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:15279899 | pubmed:issn | 0304-3835 | lld:pubmed |
| pubmed-article:15279899 | pubmed:author | pubmed-author:IsogaiEmikoE | lld:pubmed |
| pubmed-article:15279899 | pubmed:author | pubmed-author:IsogaiHiroshi... | lld:pubmed |
| pubmed-article:15279899 | pubmed:author | pubmed-author:HirataMichima... | lld:pubmed |
| pubmed-article:15279899 | pubmed:author | pubmed-author:HiroseKimihar... | lld:pubmed |
| pubmed-article:15279899 | pubmed:author | pubmed-author:AbikoYoshihir... | lld:pubmed |
| pubmed-article:15279899 | pubmed:author | pubmed-author:HosokawaYoich... | lld:pubmed |
| pubmed-article:15279899 | pubmed:author | pubmed-author:OkumuraKazuhi... | lld:pubmed |
| pubmed-article:15279899 | pubmed:author | pubmed-author:ItohAkifumiA | lld:pubmed |
| pubmed-article:15279899 | pubmed:author | pubmed-author:ShibataTakato... | lld:pubmed |
| pubmed-article:15279899 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15279899 | pubmed:day | 30 | lld:pubmed |
| pubmed-article:15279899 | pubmed:volume | 212 | lld:pubmed |
| pubmed-article:15279899 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15279899 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15279899 | pubmed:pagination | 185-94 | lld:pubmed |
| pubmed-article:15279899 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
| pubmed-article:15279899 | pubmed:meshHeading | pubmed-meshheading:15279899... | lld:pubmed |
| pubmed-article:15279899 | pubmed:meshHeading | pubmed-meshheading:15279899... | lld:pubmed |
| pubmed-article:15279899 | pubmed:meshHeading | pubmed-meshheading:15279899... | lld:pubmed |
| pubmed-article:15279899 | pubmed:meshHeading | pubmed-meshheading:15279899... | lld:pubmed |
| pubmed-article:15279899 | pubmed:meshHeading | pubmed-meshheading:15279899... | lld:pubmed |
| pubmed-article:15279899 | pubmed:meshHeading | pubmed-meshheading:15279899... | lld:pubmed |
| pubmed-article:15279899 | pubmed:meshHeading | pubmed-meshheading:15279899... | lld:pubmed |
| pubmed-article:15279899 | pubmed:meshHeading | pubmed-meshheading:15279899... | lld:pubmed |
| pubmed-article:15279899 | pubmed:meshHeading | pubmed-meshheading:15279899... | lld:pubmed |
| pubmed-article:15279899 | pubmed:meshHeading | pubmed-meshheading:15279899... | lld:pubmed |
| pubmed-article:15279899 | pubmed:meshHeading | pubmed-meshheading:15279899... | lld:pubmed |
| pubmed-article:15279899 | pubmed:meshHeading | pubmed-meshheading:15279899... | lld:pubmed |
| pubmed-article:15279899 | pubmed:meshHeading | pubmed-meshheading:15279899... | lld:pubmed |
| pubmed-article:15279899 | pubmed:meshHeading | pubmed-meshheading:15279899... | lld:pubmed |
| pubmed-article:15279899 | pubmed:meshHeading | pubmed-meshheading:15279899... | lld:pubmed |
| pubmed-article:15279899 | pubmed:meshHeading | pubmed-meshheading:15279899... | lld:pubmed |
| pubmed-article:15279899 | pubmed:meshHeading | pubmed-meshheading:15279899... | lld:pubmed |
| pubmed-article:15279899 | pubmed:meshHeading | pubmed-meshheading:15279899... | lld:pubmed |
| pubmed-article:15279899 | pubmed:meshHeading | pubmed-meshheading:15279899... | lld:pubmed |
| pubmed-article:15279899 | pubmed:meshHeading | pubmed-meshheading:15279899... | lld:pubmed |
| pubmed-article:15279899 | pubmed:meshHeading | pubmed-meshheading:15279899... | lld:pubmed |
| pubmed-article:15279899 | pubmed:meshHeading | pubmed-meshheading:15279899... | lld:pubmed |
| pubmed-article:15279899 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:15279899 | pubmed:articleTitle | C-terminal domain of human CAP18 antimicrobial peptide induces apoptosis in oral squamous cell carcinoma SAS-H1 cells. | lld:pubmed |
| pubmed-article:15279899 | pubmed:affiliation | 1st Department of Oral and Maxillofacial Surgery, School of Dentistry, Health Sciences University of Hokkaido, Ishikari-Tobetsu 1757, 061-0293, Japan. kokumura@hoku-iryo-u.ac.jp | lld:pubmed |
| pubmed-article:15279899 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15279899 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15279899 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15279899 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15279899 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15279899 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15279899 | lld:pubmed |
