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rdf:type |
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lifeskim:mentions |
umls-concept:C0007137,
umls-concept:C0007634,
umls-concept:C0030956,
umls-concept:C0086418,
umls-concept:C0162638,
umls-concept:C0205263,
umls-concept:C0442027,
umls-concept:C1136254,
umls-concept:C1413106,
umls-concept:C1514562,
umls-concept:C1707271,
umls-concept:C1880389,
umls-concept:C1883204,
umls-concept:C1883221
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pubmed:issue |
2
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pubmed:dateCreated |
2004-7-28
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pubmed:abstractText |
Mammalian myeloid and epithelial cells express many antimicrobiotic peptides that contribute to innate host defense against invading microbes. In the present study, a 27-mer peptide of the C-terminal domain (hCAP18(109-135)) and analogs of the antimicrobial peptide human cathelicidin LL-37/human cationic antimicrobial protein 18 (hCAP18) were examined for tumoricidal activity. In vitro results showed that hCAP18(109-135) induced apoptosis in human oral squamous cell carcinoma (OSCC), SAS-H1 cells. The hCAP18(109-135) induced mitochondrial depolarization and apoptosis in SAS-H1 cells, but not in healthy human gingival fibroblasts (HGF) and human keratinocyte line HaCaT cells. Caspases were not activated during hCAP18(109-135)-induced apoptosis in SAS-H1 cells. The results indicate that hCAP18(109-135) may induce caspase-independent apoptosis in OSCC but not in normal cells. hCAP18(109-135) can therefore be a useful anti-tumor therapeutic agent in the treatment of OSCC.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Anti-Infective Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Antimicrobial Cationic Peptides,
http://linkedlifedata.com/resource/pubmed/chemical/CAP18 lipopolysaccharide-binding...,
http://linkedlifedata.com/resource/pubmed/chemical/CASP3 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Caspase 3,
http://linkedlifedata.com/resource/pubmed/chemical/Caspases,
http://linkedlifedata.com/resource/pubmed/chemical/Cathelicidins,
http://linkedlifedata.com/resource/pubmed/chemical/DNA,
http://linkedlifedata.com/resource/pubmed/chemical/Peptides,
http://linkedlifedata.com/resource/pubmed/chemical/cathelicidin antimicrobial peptide
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0304-3835
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
30
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pubmed:volume |
212
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
185-94
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:15279899-Anti-Infective Agents,
pubmed-meshheading:15279899-Antimicrobial Cationic Peptides,
pubmed-meshheading:15279899-Apoptosis,
pubmed-meshheading:15279899-Carcinoma, Squamous Cell,
pubmed-meshheading:15279899-Caspase 3,
pubmed-meshheading:15279899-Caspases,
pubmed-meshheading:15279899-Cathelicidins,
pubmed-meshheading:15279899-Cell Death,
pubmed-meshheading:15279899-Cell Line, Tumor,
pubmed-meshheading:15279899-Cells, Cultured,
pubmed-meshheading:15279899-DNA,
pubmed-meshheading:15279899-DNA Fragmentation,
pubmed-meshheading:15279899-Dose-Response Relationship, Drug,
pubmed-meshheading:15279899-Enzyme Activation,
pubmed-meshheading:15279899-Fibroblasts,
pubmed-meshheading:15279899-Humans,
pubmed-meshheading:15279899-Membrane Potentials,
pubmed-meshheading:15279899-Mitochondria,
pubmed-meshheading:15279899-Mouth Neoplasms,
pubmed-meshheading:15279899-Peptides,
pubmed-meshheading:15279899-Protein Structure, Tertiary,
pubmed-meshheading:15279899-Time Factors
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pubmed:year |
2004
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pubmed:articleTitle |
C-terminal domain of human CAP18 antimicrobial peptide induces apoptosis in oral squamous cell carcinoma SAS-H1 cells.
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pubmed:affiliation |
1st Department of Oral and Maxillofacial Surgery, School of Dentistry, Health Sciences University of Hokkaido, Ishikari-Tobetsu 1757, 061-0293, Japan. kokumura@hoku-iryo-u.ac.jp
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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