Linked Life Data

15276687

Source:http://linkedlifedata.com/resource/pubmed/id/15276687

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2004-7-27
pubmed:abstractText
During inflammatory processes, the hypothalamic-pituitary axis is activated which can subsequently result in analgesia. For example, hypothalamic corticotrophin-releasing hormone (CRH) that is released during such activation has been attributed with analgesic actions. It is believed that the somatotrophic axis is also activated during inflammation. The aim of this study was to determine the analgesic actions of growth hormone-releasing hormone (GHRH), in a rat model of localized inflammatory hyperalgesia, induced by intraplantar (i.pl.) endotoxin (ET) injections. Pretreatment with intraperitoneal (i.p.) injections of GHRH (2, 5, 10 microg kg(-1)) 30 min before i.pl. ET injection (1.25 microg in 50 microl saline) prevented, in a dose-dependent manner, both mechanical hyperalgesia determined by the paw pressure (PP) test and thermal hyperalgesia determined by the hot plate (HP) and paw immersion (PI) tests. Pretreatment with GHRH had no significant effect on the elevated levels of the inflammatory mediators, interleukin (IL)-1beta, tumor necrosis factor (TNF)-alpha, IL-6 and nerve growth factor (NGF) due to i.pl. ET injection. No significant effect was obtained by pretreatment with GHRH, on the increased expression of gelatinase B due to ET injection. In conclusion, GHRH reverses inflammatory hyperalgesia in the rat without affecting the upregulated inflammatory mediators and these actions may be clinically important.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0278-5846
pubmed:author
pubmed:issnType
Print
pubmed:volume
28
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
625-31
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:15276687-Analgesics, pubmed-meshheading:15276687-Animals, pubmed-meshheading:15276687-Anti-Inflammatory Agents, Non-Steroidal, pubmed-meshheading:15276687-Behavior, Animal, pubmed-meshheading:15276687-Cytokines, pubmed-meshheading:15276687-Edema, pubmed-meshheading:15276687-Endotoxins, pubmed-meshheading:15276687-Foot, pubmed-meshheading:15276687-Gelatinases, pubmed-meshheading:15276687-Growth Hormone-Releasing Hormone, pubmed-meshheading:15276687-Hyperalgesia, pubmed-meshheading:15276687-Injections, Intraperitoneal, pubmed-meshheading:15276687-Interleukin-1, pubmed-meshheading:15276687-Interleukin-6, pubmed-meshheading:15276687-Male, pubmed-meshheading:15276687-Nerve Growth Factors, pubmed-meshheading:15276687-Pain Measurement, pubmed-meshheading:15276687-Rats, pubmed-meshheading:15276687-Rats, Sprague-Dawley, pubmed-meshheading:15276687-Tumor Necrosis Factor-alpha, pubmed-meshheading:15276687-Up-Regulation
pubmed:year
2004
pubmed:articleTitle
Growth hormone releasing hormone reverses endotoxin-induced localized inflammatory hyperalgesia without reducing the upregulated cytokines, nerve growth factor and gelatinase activity.
pubmed:affiliation
Department of Biology, Faculty of Arts and Sciences, American University of Beirut, P.O. Box 11-0236, Riad El-Solh, 1107-2020, Lebanon. rtalhouk@aub.edu.lb
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't