Source:http://linkedlifedata.com/resource/pubmed/id/15262327
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
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| pubmed:dateCreated |
2004-7-20
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| pubmed:abstractText |
The morphology, distribution and relative frequency of GABAergic neurons in the medial mamillary nucleus (MMN) of normal human individuals was studied using a glutamic acid decarboxylase (GAD) antiserum. GAD-immunoreactive (GAD-IR) neurons were found sparsely distributed throughout the MMN and most displayed a simple bipolar morphology. A small population of large diameter GAD-IR neurons was found in the white matter capsule adjacent to the ventral border of the MMN. Results of double-labeling experiments revealed no evidence of calretinin, parvalbumin or calbindin immunoreactivities co-localizing with GAD-IR neurons. GAD-IR neurons of the MMN had an average somal area of 138+/-41 microm2, compared with the average somal area of 384+/-137 microm2 for the population of MMN neurons as a whole. GAD-IR neurons had a tendency to cluster in groups of two (and occasionally three) and showed a distribution gradient across the MMN with higher densities being found near the insertion of the fornix, the origin of the mamillo-thalamic tract and toward the medial MMN border. Quantitative estimates of GAD-IR neuron frequency revealed the GAD-IR phenotype to constitute an average of 1.7% percent of the total neuron population within the human MMN. These findings suggest that inhibitory activity within the human MMN is regulated in part by a small population of intrinsic GABAergic interneurons.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:issn |
0306-4522
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
127
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
365-72
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| pubmed:dateRevised |
2007-11-15
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| pubmed:meshHeading |
pubmed-meshheading:15262327-Adult,
pubmed-meshheading:15262327-Calcium-Binding Proteins,
pubmed-meshheading:15262327-Cell Polarity,
pubmed-meshheading:15262327-Cell Size,
pubmed-meshheading:15262327-Dendrites,
pubmed-meshheading:15262327-Female,
pubmed-meshheading:15262327-Fornix, Brain,
pubmed-meshheading:15262327-Glutamate Decarboxylase,
pubmed-meshheading:15262327-Humans,
pubmed-meshheading:15262327-Immunohistochemistry,
pubmed-meshheading:15262327-Male,
pubmed-meshheading:15262327-Mamillary Bodies,
pubmed-meshheading:15262327-Middle Aged,
pubmed-meshheading:15262327-Neural Inhibition,
pubmed-meshheading:15262327-Neural Pathways,
pubmed-meshheading:15262327-Neurons,
pubmed-meshheading:15262327-Phenotype,
pubmed-meshheading:15262327-gamma-Aminobutyric Acid
|
| pubmed:year |
2004
|
| pubmed:articleTitle |
Characterization of gabaergic neurons within the human medial mamillary nucleus.
|
| pubmed:affiliation |
Department of Pathology, The University of Sydney, Sydney, NSW 2006, Australia. gavind@med.usyd.edu.au
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| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|