The introduction of copper chelates into peptide mimetics creates the Src SH2 binding ligands and paramagnetic complexes suitable for EPR studies of peptide protein interactions. The dipicolinic acid was attached to SH2 domain targeting fragments by two different linkers.
Institute for Organic Chemistry and Biochemistry, Darmstadt Technical University, Petersenstr. 22, D-64287 Darmstadt, Germany. schmibo@oc.chemie.tu-darmstadt.edu