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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1-3
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pubmed:dateCreated |
2004-7-14
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pubmed:abstractText |
In this study, we examined the role of aldose reductase (AR) in regulating the cytotoxic effects of TNF-alpha on human umbilical vein endothelial cells. Inhibition of AR by sorbinil or tolrestat prevented TNF-alpha-induced increase in Bax and Bak and the downregulation of Bcl-2. Inhibition of AR abrogated AP-1 DNA binding activity and prevented the activation of caspase-3, JNK, and p38 MAPK in cells stimulated by TNF-alpha. Exposure to TNF-alpha also induced apoptotic cell death, which was attenuated by AR inhibition or antisense ablation. These observations suggest that AR is a critical regulator of TNF-alpha-induced apoptotic signaling in endothelial cells.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Aldehyde Reductase,
http://linkedlifedata.com/resource/pubmed/chemical/BAK1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/BAX protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/CASP3 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Caspase 3,
http://linkedlifedata.com/resource/pubmed/chemical/Caspases,
http://linkedlifedata.com/resource/pubmed/chemical/Imidazoles,
http://linkedlifedata.com/resource/pubmed/chemical/Imidazolidines,
http://linkedlifedata.com/resource/pubmed/chemical/JNK Mitogen-Activated Protein...,
http://linkedlifedata.com/resource/pubmed/chemical/MAP Kinase Kinase 4,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinase...,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-bcl-2,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factor-alpha,
http://linkedlifedata.com/resource/pubmed/chemical/bcl-2 Homologous Antagonist-Killer...,
http://linkedlifedata.com/resource/pubmed/chemical/bcl-2-Associated X Protein,
http://linkedlifedata.com/resource/pubmed/chemical/p38 Mitogen-Activated Protein...,
http://linkedlifedata.com/resource/pubmed/chemical/sorbinil
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0014-5793
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
16
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pubmed:volume |
570
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
189-94
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:15251463-Aldehyde Reductase,
pubmed-meshheading:15251463-Apoptosis,
pubmed-meshheading:15251463-Caspase 3,
pubmed-meshheading:15251463-Caspases,
pubmed-meshheading:15251463-Cell Nucleus,
pubmed-meshheading:15251463-Cell Survival,
pubmed-meshheading:15251463-Cells, Cultured,
pubmed-meshheading:15251463-Cytosol,
pubmed-meshheading:15251463-Dose-Response Relationship, Drug,
pubmed-meshheading:15251463-Down-Regulation,
pubmed-meshheading:15251463-Endothelium, Vascular,
pubmed-meshheading:15251463-Humans,
pubmed-meshheading:15251463-Imidazoles,
pubmed-meshheading:15251463-Imidazolidines,
pubmed-meshheading:15251463-JNK Mitogen-Activated Protein Kinases,
pubmed-meshheading:15251463-MAP Kinase Kinase 4,
pubmed-meshheading:15251463-Membrane Proteins,
pubmed-meshheading:15251463-Microscopy, Fluorescence,
pubmed-meshheading:15251463-Mitogen-Activated Protein Kinase Kinases,
pubmed-meshheading:15251463-Mitogen-Activated Protein Kinases,
pubmed-meshheading:15251463-Phosphorylation,
pubmed-meshheading:15251463-Proto-Oncogene Proteins,
pubmed-meshheading:15251463-Proto-Oncogene Proteins c-bcl-2,
pubmed-meshheading:15251463-Signal Transduction,
pubmed-meshheading:15251463-Tumor Necrosis Factor-alpha,
pubmed-meshheading:15251463-Umbilical Veins,
pubmed-meshheading:15251463-bcl-2 Homologous Antagonist-Killer Protein,
pubmed-meshheading:15251463-bcl-2-Associated X Protein,
pubmed-meshheading:15251463-p38 Mitogen-Activated Protein Kinases
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pubmed:year |
2004
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pubmed:articleTitle |
Aldose reductase regulates TNF-alpha-induced cell signaling and apoptosis in vascular endothelial cells.
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pubmed:affiliation |
Department of Human Biological Chemistry and Genetics, University of Texas Medical Branch, 619 Basic Science Building, Galveston, TX 77555, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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