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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
2004-7-12
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pubmed:abstractText |
The functional role of HLA class II molecules in the pathogenesis of rheumatoid arthritis (RA) is unclear. HLA class II molecules are involved in the interaction between T and B lymphocytes required for long-lived B cell responses and generation of high-affinity IgG antibodies. We undertook this study to investigate the relationship between HLA class II gene polymorphisms and RA-specific IgG antibodies against cyclic citrullinated peptides (anti-CCP antibodies).
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Autoantibodies,
http://linkedlifedata.com/resource/pubmed/chemical/Biological Markers,
http://linkedlifedata.com/resource/pubmed/chemical/Epitopes,
http://linkedlifedata.com/resource/pubmed/chemical/HLA-DQ Antigens,
http://linkedlifedata.com/resource/pubmed/chemical/HLA-DQ beta-Chains,
http://linkedlifedata.com/resource/pubmed/chemical/HLA-DQB1 antigen,
http://linkedlifedata.com/resource/pubmed/chemical/HLA-DR Antigens,
http://linkedlifedata.com/resource/pubmed/chemical/HLA-DRB1*04:01 antigen,
http://linkedlifedata.com/resource/pubmed/chemical/HLA-DRB1 Chains,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin G,
http://linkedlifedata.com/resource/pubmed/chemical/Peptides, Cyclic,
http://linkedlifedata.com/resource/pubmed/chemical/cyclic citrullinated peptide
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0004-3591
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
50
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2113-21
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:15248208-Adolescent,
pubmed-meshheading:15248208-Adult,
pubmed-meshheading:15248208-Aged,
pubmed-meshheading:15248208-Aged, 80 and over,
pubmed-meshheading:15248208-Alleles,
pubmed-meshheading:15248208-Antibody Formation,
pubmed-meshheading:15248208-Arthritis, Rheumatoid,
pubmed-meshheading:15248208-Autoantibodies,
pubmed-meshheading:15248208-Biological Markers,
pubmed-meshheading:15248208-Cohort Studies,
pubmed-meshheading:15248208-Disease Progression,
pubmed-meshheading:15248208-Epitopes,
pubmed-meshheading:15248208-Female,
pubmed-meshheading:15248208-Genes, MHC Class II,
pubmed-meshheading:15248208-Genetic Predisposition to Disease,
pubmed-meshheading:15248208-Genotype,
pubmed-meshheading:15248208-HLA-DQ Antigens,
pubmed-meshheading:15248208-HLA-DQ beta-Chains,
pubmed-meshheading:15248208-HLA-DR Antigens,
pubmed-meshheading:15248208-HLA-DRB1 Chains,
pubmed-meshheading:15248208-Heterozygote,
pubmed-meshheading:15248208-Humans,
pubmed-meshheading:15248208-Immunoglobulin G,
pubmed-meshheading:15248208-Male,
pubmed-meshheading:15248208-Middle Aged,
pubmed-meshheading:15248208-Peptides, Cyclic,
pubmed-meshheading:15248208-Polymorphism, Genetic,
pubmed-meshheading:15248208-Severity of Illness Index,
pubmed-meshheading:15248208-Single-Blind Method
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pubmed:year |
2004
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pubmed:articleTitle |
Association between HLA class II genes and autoantibodies to cyclic citrullinated peptides (CCPs) influences the severity of rheumatoid arthritis.
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pubmed:affiliation |
Leiden University Medical Center, Leiden, The Netherlands. f.a.van_gaalen@lumc.nl
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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