Linked Life Data

1524567

Source:http://linkedlifedata.com/resource/pubmed/id/1524567

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
91
pubmed:dateCreated
1992-10-13
pubmed:abstractText
Antibodies against native DNA are a disease-specific marker for systemic lupus erythematosus (SLE) and in addition, there is direct evidence that these antibodies also play a major part in pathogenic mechanisms leading to systemic and organ-specific disease manifestations. The origin of anti-dsDNA antibodies is still poorly understood, especially as dsDNA per se is not immunogenic. As recently shown, evidence is now accumulating that anti-dsDNA antibodies are most likely germline-encoded and antigen-selected, as demonstrated by sequence analysis of human anti-dsDNA antibody clones from SLE patients. With regard to the possible autoantigen it is of interest that sera of SLE patients show an elevated level of nucleic acids, which at least can partly be explained by defective clearance mechanisms. The question, however, whether these nucleic acids could serve as an autoantigen triggering off anti-dsDNA antibodies has not yet been solved.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0301-0457
pubmed:author
pubmed:issnType
Print
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
197-203
pubmed:dateRevised
2005-11-16
pubmed:meshHeading
pubmed:year
1992
pubmed:articleTitle
Pathogenic aspects of systemic lupus erythematosus (SLE).
pubmed:affiliation
Department of Medicine III, University of Erlangen-Nürnberg, Germany.
pubmed:publicationType
Journal Article, Review