Linked Life Data

15243132

Source:http://linkedlifedata.com/resource/pubmed/id/15243132

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
9
pubmed:dateCreated
2004-8-27
pubmed:abstractText
The three beta AR (beta-adrenergic receptor) subtypes (beta(1)AR, beta(2)AR, and beta(3)AR) are members of the large family of G protein-coupled receptors, each of which is coupled to G alpha s and increases in intracellular cAMP levels. In white adipose tissues, catecholamine activation of the beta ARs leads to the mobilization of stored fatty acids and regulates release of several adipokines, whereas in brown adipose tissue they stimulate the specialized process of adaptive nonshivering thermogenesis. Noteworthy, in most models of obesity the beta AR system is dysfunctional, and its ability to stimulate lipolysis and thermogenesis are both impaired. Nevertheless, selective agonists for the beta(3)AR, a subtype that is found predominantly in adipocytes, have been able to prevent or reverse obesity and accompanying insulin resistance in animal models. Whether this is a viable therapeutic option for human obesity is much debated with regard to the existence of brown adipocytes in humans or their ability to be recruited. Nevertheless, probing the physiological changes in adrenoceptor function in rodent obesity, as well as the process by which beta(3)AR agonists promote a thermogenic shift in fuel use, have yielded unexpected new insights into beta AR signaling and adipocyte physiology. These include the recent discovery of an essential role of p38 MAPK in mediating adaptive thermogenesis, as well as the accessory role of the ERK MAPK pathway for the control of lipolysis. Because these metabolic events were traditionally ascribed solely to the cAMP/protein kinase A system, the integration of these signaling mechanisms may pose new therapeutic directions in the quest to counter the obesity epidemic in our midst.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0888-8809
pubmed:author
pubmed:issnType
Print
pubmed:volume
18
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2123-31
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed-meshheading:15243132-Adipocytes, pubmed-meshheading:15243132-Adipose Tissue, Brown, pubmed-meshheading:15243132-Animals, pubmed-meshheading:15243132-Base Sequence, pubmed-meshheading:15243132-Carrier Proteins, pubmed-meshheading:15243132-Humans, pubmed-meshheading:15243132-Ion Channels, pubmed-meshheading:15243132-Lipolysis, pubmed-meshheading:15243132-Membrane Proteins, pubmed-meshheading:15243132-Mitochondrial Proteins, pubmed-meshheading:15243132-Mitogen-Activated Protein Kinases, pubmed-meshheading:15243132-Molecular Sequence Data, pubmed-meshheading:15243132-Promoter Regions, Genetic, pubmed-meshheading:15243132-Receptors, Adrenergic, beta, pubmed-meshheading:15243132-Signal Transduction, pubmed-meshheading:15243132-Sympathetic Nervous System, pubmed-meshheading:15243132-Thermogenesis, pubmed-meshheading:15243132-Transcription, Genetic
pubmed:year
2004
pubmed:articleTitle
Learning new tricks from old dogs: beta-adrenergic receptors teach new lessons on firing up adipose tissue metabolism.
pubmed:affiliation
CIIT Centers for Health Research, Six Davis Drive, Research Triangle Park, North Carolina 27709, USA. scollins@ciit.org.
pubmed:publicationType
Journal Article, Review