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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2004-7-7
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pubmed:abstractText |
The NB1 glycoprotein (CD177, HNA-2a antigen) is exclusively expressed on human neutrophils. As the clinical significance of CD177 expression is unknown, we investigated its expression in healthy individuals before and after stimulation with granulocyte colony-stimulating factor (G-CSF), in patients with rheumatoid arthritis, viral hepatitis, severe bacterial infections and polycythaemia vera. Expression was quantitatively determined by flow cytometry and by real time polymerase chain reaction. Only G-CSF-stimulated individuals and patients with severe bacterial infections and polycythaemia showed a significantly (P < 0.001) increased CD177 expression compared with healthy individuals, indicating that neutrophil CD177 expression can increase significantly in certain clinical conditions.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0007-1048
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
126
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
252-4
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:15238147-Adult,
pubmed-meshheading:15238147-Arthritis, Rheumatoid,
pubmed-meshheading:15238147-Bacterial Infections,
pubmed-meshheading:15238147-Case-Control Studies,
pubmed-meshheading:15238147-Female,
pubmed-meshheading:15238147-Flow Cytometry,
pubmed-meshheading:15238147-GPI-Linked Proteins,
pubmed-meshheading:15238147-Granulocyte Colony-Stimulating Factor,
pubmed-meshheading:15238147-Hepatitis, Viral, Human,
pubmed-meshheading:15238147-Humans,
pubmed-meshheading:15238147-Isoantigens,
pubmed-meshheading:15238147-Male,
pubmed-meshheading:15238147-Membrane Glycoproteins,
pubmed-meshheading:15238147-Neutrophils,
pubmed-meshheading:15238147-Polycythemia Vera,
pubmed-meshheading:15238147-Receptors, Cell Surface,
pubmed-meshheading:15238147-Reverse Transcriptase Polymerase Chain Reaction
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pubmed:year |
2004
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pubmed:articleTitle |
Neutrophil CD177 (NB1 gp, HNA-2a) expression is increased in severe bacterial infections and polycythaemia vera.
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pubmed:affiliation |
Institute for Clinical Immunology and Transfusion Medicine & Department of Internal Medicine, Justus-Liebig University, Giessen, Germany.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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