Source:http://linkedlifedata.com/resource/pubmed/id/15233933
Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1-2
|
| pubmed:dateCreated |
2004-7-5
|
| pubmed:abstractText |
In patients with suprasellar tumors, both the tumor and its surgical resection may produce hypothalamic dysfunction including thermoregulatory disturbances. We quantitated skin sympathetic nerve activity using microneurography in eight patients with hypothalamic dysfunction following resection. Skin sympathetic nerve activity, skin blood flow (by laser Doppler flowmetry), sweating, blood pressure, and pulse rate were monitored during changes of core (tympanic) temperature in the patients and seven healthy controls. Core temperature was decreased by 0.3 degrees C and increased by 0.5 degrees C relative to baseline using a cooling/heating blanket. The increase in sympathetic nerve activity in response to cooling did not differ between controls and patients (41.0+/-13.1 vs. 38.1+/-7.7 bursts [min degrees C](-1)), but an increase upon heating in controls (45.1+/-5.4 bursts [min degrees C](-1)) was absent in the patients (-26.0+/-17.5 bursts [(min degrees C](-1)). Skin blood flow during heating increased significantly in controls but not in patients (35.6+/-14.6 vs. 15.8+/-5.8 ml [min 100 g tissue degrees C](-1)). The patients thus showed impaired heat loss during body temperature elevation. Microneurography proved to be a sensitive measure of hypothalamic autonomic function.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
May
|
| pubmed:issn |
1566-0702
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
31
|
| pubmed:volume |
112
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
80-7
|
| pubmed:dateRevised |
2009-8-12
|
| pubmed:meshHeading |
pubmed-meshheading:15233933-Adolescent,
pubmed-meshheading:15233933-Adult,
pubmed-meshheading:15233933-Aged,
pubmed-meshheading:15233933-Blood Pressure,
pubmed-meshheading:15233933-Body Temperature Regulation,
pubmed-meshheading:15233933-Case-Control Studies,
pubmed-meshheading:15233933-Central Nervous System Cysts,
pubmed-meshheading:15233933-Female,
pubmed-meshheading:15233933-Heart Rate,
pubmed-meshheading:15233933-Humans,
pubmed-meshheading:15233933-Hypothalamic Diseases,
pubmed-meshheading:15233933-Laser-Doppler Flowmetry,
pubmed-meshheading:15233933-Male,
pubmed-meshheading:15233933-Middle Aged,
pubmed-meshheading:15233933-Neurosurgical Procedures,
pubmed-meshheading:15233933-Postoperative Complications,
pubmed-meshheading:15233933-Regional Blood Flow,
pubmed-meshheading:15233933-Skin Temperature,
pubmed-meshheading:15233933-Sweating,
pubmed-meshheading:15233933-Sympathetic Nervous System,
pubmed-meshheading:15233933-Time Factors
|
| pubmed:year |
2004
|
| pubmed:articleTitle |
Altered sympathetic thermoregulation in patients with hypothalamic dysfunction following resection of suprasellar tumors.
|
| pubmed:affiliation |
Department of Neurosurgery, Nagoya University Graduate School of Medicine, Nagoya 464-8601, Japan.
|
| pubmed:publicationType |
Journal Article,
Clinical Trial,
Comparative Study
|