Linked Life Data

15225563

Source:http://linkedlifedata.com/resource/pubmed/id/15225563

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2004-6-30
pubmed:abstractText
Since oviparous fishes mobilize fat stores to produce eggs, we investigated the potential for deposition of gonadal ciguatoxins to the oil laden yolk sacs which nourish developing embryos, and characterized the effects of these toxins on finfish development. Results showed that ciguatoxins are more concentrated in the egg mass (0.18 ng/g) of a toxic fish than in the muscle (<0.04 ng/g). We used a microinjection technique in a Japanese medaka (Oryzias latipes) developmental fish model to mimic the maternal route of toxin exposure to finfish embryos. We describe the developmental effects of two preparations isolated from Caribbean great barracuda (Sphyraena barracuda): a highly purified toxin (C-CTX-1), and ciguatoxins extracted from the flesh of a toxic fish. C-CTX-1 induced a significant decrease in heart rate after four days, which did not persist with further development. Crude extracts from ciguatoxic fish flesh induced hyperkinetic twitching and severe spinal deformities. These effects were observed in embryos receiving as little as 5 pg/egg, and were consistently found in embryos receiving doses exceeding 10 pg/egg. The occurrence of twitching and spinal deformities increased in both frequency and severity with dose. Larvae suffering from spinal abnormalities were unable to orient themselves, and could not feed, resulting in mortality. The greater distribution of toxin to eggs as compared to flesh suggests that fish with low to moderate (0.5 ppb) flesh toxin levels would maternally transfer detrimental amounts of ciguatoxins to their offspring.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0041-0101
pubmed:author
pubmed:issnType
Print
pubmed:volume
44
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
59-66
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2004
pubmed:articleTitle
Characterization of the developmental toxicity of Caribbean ciguatoxins in finfish embryos.
pubmed:affiliation
Marine Biotoxins Program, Center for Coastal Environmental Health and Biomolecular Research, NOAA, National Ocean Service, Charleston, SC 29412, USA.
pubmed:publicationType
Journal Article, Comparative Study