| pubmed-article:15224159 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15224159 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:15224159 | lifeskim:mentions | umls-concept:C0376466 | lld:lifeskim |
| pubmed-article:15224159 | lifeskim:mentions | umls-concept:C0027882 | lld:lifeskim |
| pubmed-article:15224159 | lifeskim:mentions | umls-concept:C0162638 | lld:lifeskim |
| pubmed-article:15224159 | lifeskim:mentions | umls-concept:C0228174 | lld:lifeskim |
| pubmed-article:15224159 | lifeskim:mentions | umls-concept:C0019564 | lld:lifeskim |
| pubmed-article:15224159 | lifeskim:mentions | umls-concept:C0015385 | lld:lifeskim |
| pubmed-article:15224159 | lifeskim:mentions | umls-concept:C1413038 | lld:lifeskim |
| pubmed-article:15224159 | lifeskim:mentions | umls-concept:C0599946 | lld:lifeskim |
| pubmed-article:15224159 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:15224159 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:15224159 | pubmed:dateCreated | 2004-6-29 | lld:pubmed |
| pubmed-article:15224159 | pubmed:abstractText | The purpose of this study was to investigate the effects of limb ischemic preconditioning (LIP) on apoptosis of pyramidal neurons in the CA1 hippocampus induced by global cerebral ischemia-reperfusion in rats. Forty-six rats whose bilateral vertebral arteries were occluded permanently were assigned to one of four groups: sham group, limb ischemia group, cerebral ischemia group and LIP group. LIP was performed by occluding the bilateral femoral arteries for 10 min 3 times in an interval of 10 min. Global cerebral ischemia was underwent by occluding the bilateral common carotid arteries for 8 min immediately after LIP. Assays for apoptosis of the hippocampal neurons were biologically and morphologically performed using gel electrophoresis, TUNEL and AO/EB staining. Characteristic DNA ladder was clearly visualized with gel electrophoresis in the hippocampus in cerebral ischemia group, but not in LIP group. The number of TUNEL-positive cells in the CA1 hippocampus was significantly reduced by LIP from 69.8+/-12 (cerebral ischemia group) to 17.8+/-5.8 (P<0.01). AO/EB staining also showed a reduction of apoptosis in LIP group compared with cerebral ischemia group. These results suggest that LIP can inhibit hippocampal neuronal apoptosis induced by cerebral ischemia-reperfusion, which contributes to the protection against the delayed neuronal death induced by cerebral ischemic insult. | lld:pubmed |
| pubmed-article:15224159 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15224159 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15224159 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15224159 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15224159 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:15224159 | pubmed:issn | 0371-0874 | lld:pubmed |
| pubmed-article:15224159 | pubmed:author | pubmed-author:MOIII | lld:pubmed |
| pubmed-article:15224159 | pubmed:author | pubmed-author:LiWen-BinWB | lld:pubmed |
| pubmed-article:15224159 | pubmed:author | pubmed-author:ChenXiao-Ling... | lld:pubmed |
| pubmed-article:15224159 | pubmed:author | pubmed-author:LiQing-JunQJ | lld:pubmed |
| pubmed-article:15224159 | pubmed:author | pubmed-author:LiuHui-QingHQ | lld:pubmed |
| pubmed-article:15224159 | pubmed:author | pubmed-author:FengRong-Fang... | lld:pubmed |
| pubmed-article:15224159 | pubmed:author | pubmed-author:ZhaoHong-Gang... | lld:pubmed |
| pubmed-article:15224159 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15224159 | pubmed:day | 25 | lld:pubmed |
| pubmed-article:15224159 | pubmed:volume | 56 | lld:pubmed |
| pubmed-article:15224159 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15224159 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15224159 | pubmed:pagination | 407-12 | lld:pubmed |
| pubmed-article:15224159 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:15224159 | pubmed:meshHeading | pubmed-meshheading:15224159... | lld:pubmed |
| pubmed-article:15224159 | pubmed:meshHeading | pubmed-meshheading:15224159... | lld:pubmed |
| pubmed-article:15224159 | pubmed:meshHeading | pubmed-meshheading:15224159... | lld:pubmed |
| pubmed-article:15224159 | pubmed:meshHeading | pubmed-meshheading:15224159... | lld:pubmed |
| pubmed-article:15224159 | pubmed:meshHeading | pubmed-meshheading:15224159... | lld:pubmed |
| pubmed-article:15224159 | pubmed:meshHeading | pubmed-meshheading:15224159... | lld:pubmed |
| pubmed-article:15224159 | pubmed:meshHeading | pubmed-meshheading:15224159... | lld:pubmed |
| pubmed-article:15224159 | pubmed:meshHeading | pubmed-meshheading:15224159... | lld:pubmed |
| pubmed-article:15224159 | pubmed:meshHeading | pubmed-meshheading:15224159... | lld:pubmed |
| pubmed-article:15224159 | pubmed:meshHeading | pubmed-meshheading:15224159... | lld:pubmed |
| pubmed-article:15224159 | pubmed:meshHeading | pubmed-meshheading:15224159... | lld:pubmed |
| pubmed-article:15224159 | pubmed:meshHeading | pubmed-meshheading:15224159... | lld:pubmed |
| pubmed-article:15224159 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:15224159 | pubmed:articleTitle | Limb ischemic preconditioning attenuates apoptosis of pyramidal neurons in the CA1 hippocampus induced by cerebral ischemia-reperfusion in rats. | lld:pubmed |
| pubmed-article:15224159 | pubmed:affiliation | Department of Pathophysiology, Institute of Basic Medicine, Hebei Medical University, Shijiazhuang 050017, China. | lld:pubmed |
| pubmed-article:15224159 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15224159 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15224159 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15224159 | lld:pubmed |
