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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3-4
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pubmed:dateCreated |
2004-6-21
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pubmed:abstractText |
Non-cytopathogenic bovine viral diarrhoea virus (ncpBVDV) has previously been shown to inhibit the function of interferon regulatory factor-3 in cultured cells [J. Virol. 76 (2002) 8979]. In this study, we show that, like ncpBVDV, when cells were previously exposed to cytopathogenic BVDV (cpBVDV) the appearance of an IRF-3-DNA complex from nuclear extracts that can be induced by heterologous virus infection was not observed. Infection of cells with ncpBVDV or cpBVDV resulted in neither the translocation of IRF-7 from the cytoplasm to the nucleus of infected cells, nor an inhibition of its nuclear translocation in cells super-infected by Semliki Forest Virus. We conclude that cpBVDV and ncpBVDV both share the ability to inhibit the full function of IRF-3 but neither stimulate or block the nuclear uptake of IRF-7.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0165-2427
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
100
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
135-44
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pubmed:dateRevised |
2005-11-17
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pubmed:meshHeading |
pubmed-meshheading:15207451-Animals,
pubmed-meshheading:15207451-Apoptosis,
pubmed-meshheading:15207451-Bovine Virus Diarrhea-Mucosal Disease,
pubmed-meshheading:15207451-Cattle,
pubmed-meshheading:15207451-Cells, Cultured,
pubmed-meshheading:15207451-Cytopathogenic Effect, Viral,
pubmed-meshheading:15207451-DNA-Binding Proteins,
pubmed-meshheading:15207451-Diarrhea Viruses, Bovine Viral,
pubmed-meshheading:15207451-Electrophoretic Mobility Shift Assay,
pubmed-meshheading:15207451-Fluorescent Antibody Technique,
pubmed-meshheading:15207451-Interferon Regulatory Factor-3,
pubmed-meshheading:15207451-Interferon Regulatory Factor-7,
pubmed-meshheading:15207451-Proto-Oncogene Proteins c-jun,
pubmed-meshheading:15207451-Semliki forest virus,
pubmed-meshheading:15207451-Transcription Factors,
pubmed-meshheading:15207451-Virulence
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pubmed:year |
2004
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pubmed:articleTitle |
Differential activation of interferon regulatory factors-3 and -7 by non-cytopathogenic and cytopathogenic bovine viral diarrhoea virus.
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pubmed:affiliation |
Compton Laboratory, Institute for Animal Health, Compton, Newbury, Berkshire RG20 7NN, UK.
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pubmed:publicationType |
Journal Article
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