Source:http://linkedlifedata.com/resource/pubmed/id/15203249
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
6
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pubmed:dateCreated |
2004-6-18
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pubmed:abstractText |
Nociceptin/orphanin FQ/(N/OFQ), a novel heptadecapeptide recently isolated from porcine and rat brain, is the endogenous ligand of the N/OFQ peptide receptor (NOP, previously known as ORL-1). In this study we examined the effects of intracerebroventricularly (icv) injected N/OFQ on gastric emptying, gastrointestinal transit, colonic propulsion and gastric acid secretion in rats. N/OFQ (0.01-10 nmol/rat) significantly delayed gastric emptying of a phenol red meal, inhibited transit of a non-absorbable charcoal marker through the small intestine and increased the mean colonic bead expulsion time. These N/OFQ-motor effects were abolished by the NOP receptor selective antagonist [NPhe(1)]N/OFQ(1-13)-NH(2) (50 nmol/rat), but were unaltered by the classical opioid receptor antagonist, naloxone (9.2 micromol/kg). Icv injected N/OFQ (10 nmol/rat) decreased gastric acid secretion in 2-h pylorus ligated rats in a naloxone sensitive manner. [NPhe(1)]N/OFQ(1-13)-NH(2) (100 nmol/rat) icv administered alone stimulated gastric acid secretion. These results indicate that N/OFQ activates via NOP receptor stimulation a central inhibitory pathway modulating gastrointestinal propulsive activity and gastric acid secretion in rats.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Naloxone,
http://linkedlifedata.com/resource/pubmed/chemical/Opioid Peptides,
http://linkedlifedata.com/resource/pubmed/chemical/Peptide Fragments,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Opioid,
http://linkedlifedata.com/resource/pubmed/chemical/nociceptin,
http://linkedlifedata.com/resource/pubmed/chemical/nociceptin receptor,
http://linkedlifedata.com/resource/pubmed/chemical/nociceptin-(1-13)-NH2, NPhe(1)-
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0196-9781
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
25
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1013-20
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pubmed:meshHeading |
pubmed-meshheading:15203249-Animals,
pubmed-meshheading:15203249-Gastric Acid,
pubmed-meshheading:15203249-Gastric Emptying,
pubmed-meshheading:15203249-Gastrointestinal Tract,
pubmed-meshheading:15203249-Gastrointestinal Transit,
pubmed-meshheading:15203249-Injections, Intraventricular,
pubmed-meshheading:15203249-Male,
pubmed-meshheading:15203249-Naloxone,
pubmed-meshheading:15203249-Opioid Peptides,
pubmed-meshheading:15203249-Peptide Fragments,
pubmed-meshheading:15203249-Rats,
pubmed-meshheading:15203249-Rats, Wistar,
pubmed-meshheading:15203249-Receptors, Opioid
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pubmed:year |
2004
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pubmed:articleTitle |
Gastrointestinal effects of intracerebroventricularly injected nociceptin/orphaninFQ in rats.
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pubmed:affiliation |
Department of Human Physiology and Pharmacology, University "La Sapienza" Ple A. Moro 5-00185, Rome, Italy.
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pubmed:publicationType |
Journal Article
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