Source:http://linkedlifedata.com/resource/pubmed/id/15201997
Switch to
Predicate | Object |
---|---|
rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
|
pubmed:dateCreated |
2004-6-17
|
pubmed:abstractText |
We previously conducted a trial of an 'individualized' regimen, in which cancer patients were vaccinated with peptides after the confirmation of pre-existing peptide-specific cytotoxic T lymphocyte (CTL) precursors. In this study, we performed a new trial of 'pre-designated' regimen, in which cancer patients were vaccinated with peptides that were frequently selected as vaccine candidates in the preceding individualized regimen. Eighteen cancer patients (10 with uterine cervical cancer and 8 with gastric cancer) were enrolled in the new regimen. The pre-designated regimen was well tolerated by all patients. Although peptide-specific CTL precursors and humoral responses increased in the majority of patients with the pre-designated regimen, neither of the responses correlated with clinical outcome. Three patients had long stable disease, and their pre-vaccination peripheral blood mononuclear cells contained peptide-specific CTL precursors reactive to more than 2 of 4 peptides. With the pre-designated regimen, the levels of pre-existing immunoglobulin G reactive to non-vaccinated peptides decreased in 5 of 15 patients with progressive disease, and their time to progression was very short, whereas such a decrease was rarely observed in the preceding individualized regimen. These results suggest that the pre-designated regimen can elicit a primary immune response, but may incidentally suppress pre-existing immune responses.
|
pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Jul
|
pubmed:issn |
1019-6439
|
pubmed:author |
pubmed-author:HaradaMamoruM,
pubmed-author:ItohKyogoK,
pubmed-author:KamuraToshiharuT,
pubmed-author:KatagiriKazukoK,
pubmed-author:MaedaYoshiakiY,
pubmed-author:MatsuuraKimioK,
pubmed-author:MochizukiKazuoK,
pubmed-author:SakamotoMasaruM,
pubmed-author:SatoYujiY,
pubmed-author:ShomuraHirokiH,
pubmed-author:TodoSatoruS,
pubmed-author:TsudaNaotakeN,
pubmed-author:UshijimaKimioK,
pubmed-author:YamadaAkiraA
|
pubmed:issnType |
Print
|
pubmed:volume |
25
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
121-31
|
pubmed:dateRevised |
2006-11-15
|
pubmed:meshHeading |
pubmed-meshheading:15201997-Adult,
pubmed-meshheading:15201997-Aged,
pubmed-meshheading:15201997-Antibody Formation,
pubmed-meshheading:15201997-Cancer Vaccines,
pubmed-meshheading:15201997-Female,
pubmed-meshheading:15201997-Humans,
pubmed-meshheading:15201997-Hypersensitivity, Delayed,
pubmed-meshheading:15201997-Immunity, Cellular,
pubmed-meshheading:15201997-Male,
pubmed-meshheading:15201997-Middle Aged,
pubmed-meshheading:15201997-Peptide Fragments,
pubmed-meshheading:15201997-T-Lymphocytes, Cytotoxic,
pubmed-meshheading:15201997-Uterine Cervical Neoplasms
|
pubmed:year |
2004
|
pubmed:articleTitle |
Immunological evaluation of vaccination with pre-designated peptides frequently selected as vaccine candidates in an individualized peptide vaccination regimen.
|
pubmed:affiliation |
Department of Gynecology, Kurume University, School of Medicine, Fukuoka 830-0011, Japan.
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|