Source:http://linkedlifedata.com/resource/pubmed/id/15194190
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:dateCreated |
2004-6-14
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| pubmed:abstractText |
Transfer RNA (tRNA)-like sequences were searched for in the nine basic taxonomic divisions of GenBank-121 (viruses, phages, bacteria, plants, invertebrates, vertebrates, rodents, mammals, and primates) by an original program package implementing a dynamic profile alignment approach for the genetic texts' analysis, in using 22 profiles of tRNAs of different isotypes. In total, 175,901 previously unknown tRNA-like sequences were revealed. The locations of the tRNA-likes were considered over the regions whose functional meaning is described by standard Feature Keys in GenBank. Many regions containing the tRNA-like sequences were recognized as known repeats. A mode of distribution of the tRNA-like sequences in a genome was proposed as expansion in a content of the various transposable elements. An analysis of the integrity of RNA polymerase III inner promoters in the tRNA-like sequences over the GenBank divisions has shown a high possibility of generating new copies of short interspersed nuclear element (SINE) repeats in all divisions, excepting primates. The numerous tRNA-likes found in the regions of RNA polymerase II promoters have suggested an adaptation of RNA polymerase III promoter to a binding of RNA polymerase II.
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| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Jun
|
| pubmed:issn |
0378-1119
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
23
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| pubmed:volume |
335
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
57-71
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| pubmed:dateRevised |
2008-11-21
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| pubmed:meshHeading |
pubmed-meshheading:15194190-Algorithms,
pubmed-meshheading:15194190-Animals,
pubmed-meshheading:15194190-Base Composition,
pubmed-meshheading:15194190-Base Sequence,
pubmed-meshheading:15194190-DNA,
pubmed-meshheading:15194190-DNA Transposable Elements,
pubmed-meshheading:15194190-Databases, Nucleic Acid,
pubmed-meshheading:15194190-Eukaryotic Cells,
pubmed-meshheading:15194190-Evolution, Molecular,
pubmed-meshheading:15194190-Genetic Variation,
pubmed-meshheading:15194190-Genome,
pubmed-meshheading:15194190-Humans,
pubmed-meshheading:15194190-Molecular Sequence Data,
pubmed-meshheading:15194190-Nucleic Acid Conformation,
pubmed-meshheading:15194190-Prokaryotic Cells,
pubmed-meshheading:15194190-RNA, Transfer,
pubmed-meshheading:15194190-Regulatory Sequences, Nucleic Acid,
pubmed-meshheading:15194190-Repetitive Sequences, Nucleic Acid,
pubmed-meshheading:15194190-Sequence Alignment
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| pubmed:year |
2004
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| pubmed:articleTitle |
Evolution of tRNA-like sequences and genome variability.
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| pubmed:affiliation |
Centre Bioengineering RAS, Prospekt 60-letiya Oktyabrya, 7/1, Moscow 117312, Russia. felix@biengi.ac.ru
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| pubmed:publicationType |
Journal Article,
Comparative Study
|