Linked Life Data

15190177

Source:http://linkedlifedata.com/resource/pubmed/id/15190177

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
23
pubmed:dateCreated
2004-6-10
pubmed:abstractText
Normal "healthy" aging is defined as aging without disease. Many aged people do not exhibit symptoms of disease and lead normal lives, but nonetheless display pathological changes that are characteristic of Alzheimer's disease (AD), Parkinson's disease (PD), dementia with Lewy bodies (DLB), and/or cerebrovascular disease (CVD). These changes are restricted to distinct brain regions and might represent preclinical stages of these disorders. This Perspective discusses arguments in favor of and against the hypothesis that pathological changes related to AD, PD, DLB, and CVD in the brains of nondemented elderly people represent early stages of these diseases rather than healthy aging. We conclude that early pathological disease-related changes do indeed constitute the beginning of AD, PD, DLB, and CVD rather than normal concomitants of aging, even in the absence of any clinical symptoms. Aging is, therefore, a major risk factor for these diseases but does not necessarily lead to age-related diseases.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
1539-6150
pubmed:author
pubmed:issnType
Electronic
pubmed:day
9
pubmed:volume
2004
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
pe26
pubmed:dateRevised
2005-11-16
pubmed:meshHeading
pubmed:year
2004
pubmed:articleTitle
Neurodegeneration in normal brain aging and disease.
pubmed:affiliation
Department of Neuropathology, University of Bonn Medical Center, Sigmund Freud Strasse 25, D-53105 Bonn, Germany. Dietmar.Thal@uni-bonn.de
pubmed:publicationType
Journal Article, Review