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rdf:type |
|
|
lifeskim:mentions |
|
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pubmed:issue |
8
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pubmed:dateCreated |
2004-7-14
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pubmed:abstractText |
In human glomerulonephritis, including immunoglobulin-A nephropathy (IgAN), glomerular expression of macrophage migration inhibitory factor (MIF) is found to correlate with progressive renal injury. We have shown previously that polymeric IgA is capable of inducing MIF production in cultured human mesangial cells, suggesting a role in inducing inflammatory injury in IgAN. Herein, we examined whether IgA deposition and the subsequent renal injury can be ameliorated with anti-MIF treatment in an experimental murine model of IgAN.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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|
pubmed:month |
Aug
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|
pubmed:issn |
0931-0509
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:volume |
19
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1976-85
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:15187193-Animals,
pubmed-meshheading:15187193-Antibodies, Monoclonal,
pubmed-meshheading:15187193-Gene Expression,
pubmed-meshheading:15187193-Glomerulonephritis, IGA,
pubmed-meshheading:15187193-Immunoblotting,
pubmed-meshheading:15187193-Immunohistochemistry,
pubmed-meshheading:15187193-Macrophage Migration-Inhibitory Factors,
pubmed-meshheading:15187193-Mice,
pubmed-meshheading:15187193-Mice, Inbred BALB C,
pubmed-meshheading:15187193-Transforming Growth Factor beta,
pubmed-meshheading:15187193-Transforming Growth Factor beta1,
pubmed-meshheading:15187193-Up-Regulation
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|
pubmed:year |
2004
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|
pubmed:articleTitle |
Anti-macrophage migration inhibitory factor reduces transforming growth factor-beta 1 expression in experimental IgA nephropathy.
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pubmed:affiliation |
Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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