Linked Life Data

15185341

Source:http://linkedlifedata.com/resource/pubmed/id/15185341

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2004-6-8
pubmed:abstractText
Hypoxia-inducible factor (HIF)-1 alpha is the regulatory subunit of HIF-1 that is stabilized under hypoxic conditions. Under different circumstances, HIF-1 alpha may promote both tumorigenesis and apoptosis. There is conflicting data on the importance of HIF-1 alpha as a prognostic factor. This study evaluated HIF-1 alpha expression in 172 consecutive patients with stage I-IIIA non small cell lung cancer (NSCLC) using standard immunohistochemical techniques. The extent of HIF-1 alpha nuclear immunostaining was determined using light microscopy and the results were analyzed using the median (5%) as a low cut-point and 60% as a high positive cut-point. Using the low cut-point, positive associations were found with epidermal growth factor receptor (EGFR; p = 0.01), matrix metalloproteinase (MMP)-9 (p = 0.003), membranous (p < 0.001) and perinuclear (p = 0.004) carbonic anhydrase (CA) IX, p53 (p = 0.008), T-stage (p = 0.042), tumor necrosis (TN; p < 0.001) and squamous histology (p < 0.001). No significant association was found with Bcl-2 or either N- or overall TMN stage or prognosis. When the high positive cut-point was used, HIF-1 alpha was associated with a poor prognosis (p = 0.034). In conclusion, the associations with EGFR, MMP-9, p53 and CA IX suggest that these factors may either regulate or be regulated by HIF-1 alpha. The association with TN and squamous-type histology, which is relatively more necrotic than other NSCLC types, reflects the role of hypoxia in the regulation of HIF-1 alpha. The prognostic data may reflect a change in the behavior of HIF-1 alpha in increasingly hypoxic environments.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0020-7136
pubmed:author
pubmed:copyrightInfo
Copyright 2004 Wiley-Liss, Inc.
pubmed:issnType
Print
pubmed:day
10
pubmed:volume
111
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
43-50
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed-meshheading:15185341-Adult, pubmed-meshheading:15185341-Aged, pubmed-meshheading:15185341-Apoptosis, pubmed-meshheading:15185341-Carbonic Anhydrases, pubmed-meshheading:15185341-Carcinoma, Non-Small-Cell Lung, pubmed-meshheading:15185341-Cell Hypoxia, pubmed-meshheading:15185341-Cross-Sectional Studies, pubmed-meshheading:15185341-Female, pubmed-meshheading:15185341-Gene Expression Regulation, Neoplastic, pubmed-meshheading:15185341-Humans, pubmed-meshheading:15185341-Hypoxia-Inducible Factor 1, alpha Subunit, pubmed-meshheading:15185341-Immunohistochemistry, pubmed-meshheading:15185341-Lung Neoplasms, pubmed-meshheading:15185341-Male, pubmed-meshheading:15185341-Matrix Metalloproteinase 9, pubmed-meshheading:15185341-Middle Aged, pubmed-meshheading:15185341-Necrosis, pubmed-meshheading:15185341-Neoplasm Staging, pubmed-meshheading:15185341-Prognosis, pubmed-meshheading:15185341-Receptor, Epidermal Growth Factor, pubmed-meshheading:15185341-Transcription Factors, pubmed-meshheading:15185341-Tumor Markers, Biological
pubmed:year
2004
pubmed:articleTitle
Hypoxia-inducible factor-1 alpha in non small cell lung cancer: relation to growth factor, protease and apoptosis pathways.
pubmed:affiliation
Cancer Centre, Queen Elizabeth Hospital, Birmingham, United Kingdom. daniel.swinson@fsmail.net
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't