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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2004-8-31
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pubmed:abstractText |
Preclinical studies have demonstrated a synergistic effect with the angiogenesis inhibitor TNP-470 and several cytotoxic agents. A recent clinical trial with the combination of paclitaxel and TNP-470 has shown promising effects. The present study was designed to determine the toxicity and pharmacokinetics of carboplatin in combination with TNP-470 in comparison with the doublet regimen of paclitaxel and carboplatin in patients with solid tumors.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0344-5704
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pubmed:author |
pubmed-author:BlumenscheinGeorge RGRJr,
pubmed-author:FossellaFrank VFV,
pubmed-author:HerbstRoy SRS,
pubmed-author:LuCharlesC,
pubmed-author:MaddenTimothyT,
pubmed-author:MeyersChristina ACA,
pubmed-author:MundenReggieR,
pubmed-author:PapadimitrakopoulouValiV,
pubmed-author:PuduvalliVinay KVK,
pubmed-author:SmytheLori GLG,
pubmed-author:TranHai THT,
pubmed-author:TruongMyleneM,
pubmed-author:ZinnerRalphR
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pubmed:issnType |
Print
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pubmed:volume |
54
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
308-14
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:15184994-Adult,
pubmed-meshheading:15184994-Aged,
pubmed-meshheading:15184994-Angiogenesis Inhibitors,
pubmed-meshheading:15184994-Antineoplastic Combined Chemotherapy Protocols,
pubmed-meshheading:15184994-Carboplatin,
pubmed-meshheading:15184994-Cyclohexanes,
pubmed-meshheading:15184994-Female,
pubmed-meshheading:15184994-Humans,
pubmed-meshheading:15184994-Lung Neoplasms,
pubmed-meshheading:15184994-Male,
pubmed-meshheading:15184994-Middle Aged,
pubmed-meshheading:15184994-Neoplasms,
pubmed-meshheading:15184994-Paclitaxel,
pubmed-meshheading:15184994-Sesquiterpenes
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pubmed:year |
2004
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pubmed:articleTitle |
Clinical and pharmacokinetic study of TNP-470, an angiogenesis inhibitor, in combination with paclitaxel and carboplatin in patients with solid tumors.
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pubmed:affiliation |
Department of Thoracic/Head and Neck Medical Oncology, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Blvd., Unit 432, Houston, TX 77030, USA. htran@mdanderson.org
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Research Support, Non-U.S. Gov't
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