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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2004-6-8
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pubmed:abstractText |
Celecoxib was shown to regress colorectal adenomas in familial adenomatous polyposis (FAP) patients relative to placebo. To address the mechanism of polyp regression, we determined whether celecoxib can modulate cell proliferation, apoptosis, and prostaglandin E(2) (PGE(2)) levels in colorectal epithelia from FAP trial participants and whether such alterations correlate with observed reductions in polyp number.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1055-9965
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pubmed:author |
pubmed-author:AyersGregory DGD,
pubmed-author:CohenDeborah SDS,
pubmed-author:Familial Adenomatous Polyposis Study Group,
pubmed-author:HalfElizabethE,
pubmed-author:HawkErnest TET,
pubmed-author:LevinBernardB,
pubmed-author:LynchPatrick MPM,
pubmed-author:MorrisJeffrey SJS,
pubmed-author:MorrowJason DJD,
pubmed-author:SinicropeFrank AFA,
pubmed-author:StephensL CliftonLC
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pubmed:issnType |
Print
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pubmed:volume |
13
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
920-7
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:15184247-Adenomatous Polyposis Coli,
pubmed-meshheading:15184247-Adolescent,
pubmed-meshheading:15184247-Adult,
pubmed-meshheading:15184247-Aged,
pubmed-meshheading:15184247-Anti-Inflammatory Agents, Non-Steroidal,
pubmed-meshheading:15184247-Antineoplastic Agents,
pubmed-meshheading:15184247-Apoptosis,
pubmed-meshheading:15184247-Biological Markers,
pubmed-meshheading:15184247-Colorectal Neoplasms,
pubmed-meshheading:15184247-Cyclooxygenase Inhibitors,
pubmed-meshheading:15184247-Dinoprostone,
pubmed-meshheading:15184247-Double-Blind Method,
pubmed-meshheading:15184247-Humans,
pubmed-meshheading:15184247-Immunoenzyme Techniques,
pubmed-meshheading:15184247-Intestinal Mucosa,
pubmed-meshheading:15184247-Ki-67 Antigen,
pubmed-meshheading:15184247-Mass Spectrometry,
pubmed-meshheading:15184247-Middle Aged,
pubmed-meshheading:15184247-Placebos,
pubmed-meshheading:15184247-Pyrazoles,
pubmed-meshheading:15184247-Remission Induction,
pubmed-meshheading:15184247-Sulfonamides
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pubmed:year |
2004
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pubmed:articleTitle |
Cell proliferation and apoptotic indices predict adenoma regression in a placebo-controlled trial of celecoxib in familial adenomatous polyposis patients.
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pubmed:affiliation |
Department of Gastrointestinal Medicine and Nutrition, University of Texas M. D. Anderson Cancer Center, Houston, USA. sinicrope.frank@mayo.edu
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Randomized Controlled Trial
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