Linked Life Data

15183444

Source:http://linkedlifedata.com/resource/pubmed/id/15183444

Statements in which the resource exists.
SubjectPredicateObjectContext
pubmed-article:15183444rdf:typepubmed:Citationlld:pubmed
pubmed-article:15183444lifeskim:mentionsumls-concept:C0039508lld:lifeskim
pubmed-article:15183444lifeskim:mentionsumls-concept:C0016030lld:lifeskim
pubmed-article:15183444lifeskim:mentionsumls-concept:C0078058lld:lifeskim
pubmed-article:15183444lifeskim:mentionsumls-concept:C0080194lld:lifeskim
pubmed-article:15183444lifeskim:mentionsumls-concept:C0215848lld:lifeskim
pubmed-article:15183444lifeskim:mentionsumls-concept:C0965644lld:lifeskim
pubmed-article:15183444lifeskim:mentionsumls-concept:C0017262lld:lifeskim
pubmed-article:15183444lifeskim:mentionsumls-concept:C1333897lld:lifeskim
pubmed-article:15183444lifeskim:mentionsumls-concept:C1704838lld:lifeskim
pubmed-article:15183444lifeskim:mentionsumls-concept:C1171892lld:lifeskim
pubmed-article:15183444lifeskim:mentionsumls-concept:C2003941lld:lifeskim
pubmed-article:15183444lifeskim:mentionsumls-concept:C0439596lld:lifeskim
pubmed-article:15183444lifeskim:mentionsumls-concept:C2911684lld:lifeskim
pubmed-article:15183444lifeskim:mentionsumls-concept:C0185117lld:lifeskim
pubmed-article:15183444pubmed:issue4lld:pubmed
pubmed-article:15183444pubmed:dateCreated2004-6-8lld:pubmed
pubmed-article:15183444pubmed:abstractTextNeovascularization is involved in beneficial and detrimental processes of tendon pathology. We investigated the influence of repetitive motion on the expression of the most important angiogenic factor, the vascular endothelial growth factor (VEGF) in the 3T3 NIH fibroblast cell line and in cultures of rat Achilles tendon fibroblasts. Monolayers of subconfluently grown cells were stretched in rectangular silicone dishes with cyclic uniaxial movement. Strain was applied over 24 h varying the frequency (0.5-1 Hz). Fibroblasts (3T3 fibroblasts and rat Achilles tendon cultures) cultivated without the application of cyclic strain released measurable VEGF amounts into their culture supernatants. Cyclic stretching of the cells with a frequency of 1 Hz resulted in an increased expression of VEGF. A low frequency (0.5 Hz) reduced VEGF expression to control levels. RT PCR revealed VEGF 121 and VEGF 165 as the only splice forms that were induced by cyclic stretching. Western blot experiments could further show that cyclic stretching induced activation of the transcription factor HIF-1alpha. These results demonstrate that mechanical factors are involved in the regulation of VEGF expression in tendon tissue.lld:pubmed
pubmed-article:15183444pubmed:languageenglld:pubmed
pubmed-article:15183444pubmed:journalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15183444pubmed:citationSubsetIMlld:pubmed
pubmed-article:15183444pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15183444pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15183444pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15183444pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15183444pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15183444pubmed:statusMEDLINElld:pubmed
pubmed-article:15183444pubmed:monthJullld:pubmed
pubmed-article:15183444pubmed:issn0736-0266lld:pubmed
pubmed-article:15183444pubmed:authorpubmed-author:HassenpflugJo...lld:pubmed
pubmed-article:15183444pubmed:authorpubmed-author:MentleinRolfRlld:pubmed
pubmed-article:15183444pubmed:authorpubmed-author:PetersenWolfWlld:pubmed
pubmed-article:15183444pubmed:authorpubmed-author:PufeThomasTlld:pubmed
pubmed-article:15183444pubmed:authorpubmed-author:VarogaDeikeDlld:pubmed
pubmed-article:15183444pubmed:authorpubmed-author:ZantopThoreTlld:pubmed
pubmed-article:15183444pubmed:issnTypePrintlld:pubmed
pubmed-article:15183444pubmed:volume22lld:pubmed
pubmed-article:15183444pubmed:ownerNLMlld:pubmed
pubmed-article:15183444pubmed:authorsCompleteYlld:pubmed
pubmed-article:15183444pubmed:pagination847-53lld:pubmed
pubmed-article:15183444pubmed:dateRevised2006-11-15lld:pubmed
pubmed-article:15183444pubmed:meshHeadingpubmed-meshheading:15183444...lld:pubmed
pubmed-article:15183444pubmed:meshHeadingpubmed-meshheading:15183444...lld:pubmed
pubmed-article:15183444pubmed:meshHeadingpubmed-meshheading:15183444...lld:pubmed
pubmed-article:15183444pubmed:meshHeadingpubmed-meshheading:15183444...lld:pubmed
pubmed-article:15183444pubmed:meshHeadingpubmed-meshheading:15183444...lld:pubmed
pubmed-article:15183444pubmed:meshHeadingpubmed-meshheading:15183444...lld:pubmed
pubmed-article:15183444pubmed:meshHeadingpubmed-meshheading:15183444...lld:pubmed
pubmed-article:15183444pubmed:meshHeadingpubmed-meshheading:15183444...lld:pubmed
pubmed-article:15183444pubmed:meshHeadingpubmed-meshheading:15183444...lld:pubmed
pubmed-article:15183444pubmed:meshHeadingpubmed-meshheading:15183444...lld:pubmed
pubmed-article:15183444pubmed:meshHeadingpubmed-meshheading:15183444...lld:pubmed
pubmed-article:15183444pubmed:meshHeadingpubmed-meshheading:15183444...lld:pubmed
pubmed-article:15183444pubmed:meshHeadingpubmed-meshheading:15183444...lld:pubmed
pubmed-article:15183444pubmed:meshHeadingpubmed-meshheading:15183444...lld:pubmed
pubmed-article:15183444pubmed:meshHeadingpubmed-meshheading:15183444...lld:pubmed
pubmed-article:15183444pubmed:meshHeadingpubmed-meshheading:15183444...lld:pubmed
pubmed-article:15183444pubmed:meshHeadingpubmed-meshheading:15183444...lld:pubmed
pubmed-article:15183444pubmed:meshHeadingpubmed-meshheading:15183444...lld:pubmed
pubmed-article:15183444pubmed:year2004lld:pubmed
pubmed-article:15183444pubmed:articleTitleCyclic strain influences the expression of the vascular endothelial growth factor (VEGF) and the hypoxia inducible factor 1 alpha (HIF-1alpha) in tendon fibroblasts.lld:pubmed
pubmed-article:15183444pubmed:affiliationDepartment of Trauma, Hand, and Reconstructive Surgery, Westfaelische Wilhelms University, 48149 Muenster, Germany. wolfpetersen@hotmail.comlld:pubmed
pubmed-article:15183444pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:15183444pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15183444lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15183444lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15183444lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15183444lld:pubmed