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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
13
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pubmed:dateCreated |
2004-6-4
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pubmed:abstractText |
The reactants of an anti-malarial peroxide having a 6-carbomethoxymethyl-3-methoxy-1,2-dioxane moiety treated with FeSO4 were analyzed. For mechanistic study of the anti-malarial peroxide, two biotinylated probes to elucidate the target molecules were designed and synthesized. The two synthesized probes showed potent anti-malarial activity, and one of them was proved to form an irreversible binding with protein in a model experiment.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0960-894X
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:day |
5
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pubmed:volume |
14
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3513-6
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:15177463-Antimalarials,
pubmed-meshheading:15177463-Biosensing Techniques,
pubmed-meshheading:15177463-Dioxanes,
pubmed-meshheading:15177463-Drug Design,
pubmed-meshheading:15177463-Ferrous Compounds,
pubmed-meshheading:15177463-Humans,
pubmed-meshheading:15177463-Models, Biological,
pubmed-meshheading:15177463-Models, Chemical,
pubmed-meshheading:15177463-Peroxides,
pubmed-meshheading:15177463-Protein Binding,
pubmed-meshheading:15177463-Time Factors
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pubmed:year |
2004
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pubmed:articleTitle |
Synthesis of a bioprobe for elucidation of target molecule of spongean anti-malarial peroxides.
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pubmed:affiliation |
Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamada-oka, Suita, Osaka 565-0871, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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