|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
13
|
|
pubmed:dateCreated |
2004-6-4
|
|
pubmed:abstractText |
Structurally modified 3-(N-benzylamino)propylphosphonic acid S1P receptor agonists that maintain affinity for S1P1, and have decreased affinity for S1P3 are efficacious, but exhibit decreased acute cardiovascular toxicity in rodents than do nonselective agonists.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jul
|
|
pubmed:issn |
0960-894X
|
|
pubmed:author |
pubmed-author:BergstromJamesJ,
pubmed-author:CardDeborahD,
pubmed-author:ChrebetGaryG,
pubmed-author:DohertyGeorgeG,
pubmed-author:ForrestMichaelM,
pubmed-author:HajduRichardR,
pubmed-author:HaleJeffrey JJJ,
pubmed-author:KeohaneCarol AnnCA,
pubmed-author:MandalaSuzanneS,
pubmed-author:MilliganJamesJ,
pubmed-author:MillsSander GSG,
pubmed-author:NomuraNaomiN,
pubmed-author:RosenHughH,
pubmed-author:RosenbachMarkM,
pubmed-author:SheiGan-JuGJ,
pubmed-author:SunShu-YuSY,
pubmed-author:TothLeslieL,
pubmed-author:WestSarahS,
pubmed-author:XieHuijuanH
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
5
|
|
pubmed:volume |
14
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
3501-5
|
|
pubmed:dateRevised |
2005-11-17
|
|
pubmed:meshHeading |
pubmed-meshheading:15177461-Animals,
pubmed-meshheading:15177461-Benzyl Compounds,
pubmed-meshheading:15177461-Binding Sites,
pubmed-meshheading:15177461-CHO Cells,
pubmed-meshheading:15177461-Cardiovascular System,
pubmed-meshheading:15177461-Cricetinae,
pubmed-meshheading:15177461-Humans,
pubmed-meshheading:15177461-Inhibitory Concentration 50,
pubmed-meshheading:15177461-Kinetics,
pubmed-meshheading:15177461-Lysophospholipids,
pubmed-meshheading:15177461-Mice,
pubmed-meshheading:15177461-Myocardium,
pubmed-meshheading:15177461-Organophosphorus Compounds,
pubmed-meshheading:15177461-Phosphorus Radioisotopes,
pubmed-meshheading:15177461-Rats,
pubmed-meshheading:15177461-Receptors, G-Protein-Coupled,
pubmed-meshheading:15177461-Receptors, Lysosphingolipid,
pubmed-meshheading:15177461-Sphingosine
|
|
pubmed:year |
2004
|
|
pubmed:articleTitle |
Selecting against S1P3 enhances the acute cardiovascular tolerability of 3-(N-benzyl)aminopropylphosphonic acid S1P receptor agonists.
|
|
pubmed:affiliation |
Department of Medicinal Chemistry, Merck Research Laboratories, Rahway, NJ 07065, USA. jeffrey_hale@merck.com
|
|
pubmed:publicationType |
Journal Article
|
